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Here, we designed a hierarchically channeled graphitized nanoarchitecture (HPGC\u2010Z67) as a novel nano\u2010diagnostic platform. HPGC\u2010Z67 features high graphitization and interconnected multi\u2010scale channeled structures that facilitate N\u2010glycan retention and mass transfer in expanded porous channels. Notably, compared to traditional protocol, this HPGC\u2010Z67 platform reduces processing time by about 25\u00a0min and cost by approximately CNY 30 per plasma sample, making it suitable for large\u2010scale clinical diagnostics. The HPGC\u2010Z67 nano\u2010diagnostic platform enables sensitive extraction of N\u2010glycan profiles from 150 plasma samples. Notably, two pivotal N\u2010glycans are identified, one sensitive to infectious fever (IF\u2010sensitive) and the other to non\u2010infectious fever (n\u2010IF\u2010sensitive), which together enable simultaneous differentiation of ERMF, CAM, and healthy controls with area under the curve values of 0.965 in the training set and 0.914 in the validation set, respectively. This HPGC\u2010Z67 nano\u2010diagnostic platform advances glycomics towards precise diagnostics and timely clinical intervention.<\/jats:p>","DOI":"10.1002\/advs.202521251","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:33:05Z","timestamp":1773012785000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hierarchical Channeled Graphitized Nanoarchitecture as a Diagnostic Platform for Maternal Fever Warning"],"prefix":"10.1002","volume":"13","author":[{"given":"Yiwen","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Chemistry Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Key Lab of Reproduction and Development Shanghai Key Lab of Female Reproductive Endocrine Related Diseases Obstetrics &amp; Gynecology Hospital of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heyuhan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemistry Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xufang","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Chemical Science and Technology National Demonstration Center for Experimental Chemistry and Chemical Engineering Education Yunnan University  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Key Lab of Reproduction and Development Shanghai Key Lab of Female Reproductive Endocrine Related Diseases Obstetrics &amp; Gynecology Hospital of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8704-7543","authenticated-orcid":false,"given":"Chunhui","family":"Deng","sequence":"additional","affiliation":[{"name":"Center for Medical Research and Innovation Shanghai Pudong Hospital Fudan University Pudong Medical Center Department of Chemistry Institutes of Biomedical Sciences Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952\u20108180(03)00081\u20103"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000000646"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181f713d4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1389132"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550030087041"},{"key":"e_1_2_9_7_1","first-page":"274","article-title":"Chorioamnionitis and the Prognosis for Term Infants","volume":"94","author":"Alexander J. 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