{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T11:04:00Z","timestamp":1775127840443,"version":"3.50.1"},"reference-count":60,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Therapy targeting cancer stem cells (CSCs) has been proposed as a promising strategy to reduce chemoresistance and relapse risks in ovarian cancer (OC) patients. However, the lack of targetable markers impedes research progress. Here, we demonstrate that CXC motif chemokine receptor 4 (CXCR4) may be a targetable functional marker of ovarian CSCs and propose a new translational model incorporating targeted imaging and CXCR4 blockade in CXCR4\n                    <jats:sup>+<\/jats:sup>\n                    tumors. Expression profile analysis of chemoresistant CSC\u2010like ovarian cancer cells highlighted that CXCR4 functions as a potential stemness marker. CXCR4\n                    <jats:sup>+<\/jats:sup>\n                    ovarian cancer cells exhibited high self\u2010renewal capacity in vitro and in vivo, and an association with chemoresistance. CXCR4 inhibitor AMD3100 significantly impaired the self\u2010renewal ability of CSC\u2010like ovarian cancer cells and enhanced their sensitivity to cisplatin. CXCR4\u2010targeted [\n                    <jats:sup>68<\/jats:sup>\n                    Ga]Ga\u2010Pentixafor was highly specific in delineating CXCR4\u2010high cell line\u2010derived xenografts and patient\u2010derived xenografts (PDXs) via positron emission tomography (PET) imaging, with precise tumor\u2010targeting and persistent retention. A combination of AMD3100 and CDDP exerted an excellent antitumor effect in CXCR4\u2010high PDXs, but not in CXCR4\u2010low PDXs. These results suggest that CXCR4 may represent a functional CSC marker associated with chemoresistance. Moreover, [\n                    <jats:sup>68<\/jats:sup>\n                    Ga]Ga\u2010Pentixafor PET imaging can guide decision\u2010making for AMD3100 therapy, paving the way for further clinical translation.\n                  <\/jats:p>","DOI":"10.1002\/advs.202521279","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T15:48:16Z","timestamp":1770133696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mapping CSC\u2010Mediated Ovarian Cancer Chemoresistance via CXCR4\u2010PET to Guide Precision Cisplatin Re\u2010Sensitization Therapy"],"prefix":"10.1002","volume":"13","author":[{"given":"Lixia","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"},{"name":"Department of Nuclear Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"},{"name":"Hubei Key Laboratory of Molecular Imaging Wuhan China"},{"name":"Key Laboratory of Biological Targeted Therapy The Ministry of Education Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Third Hospital of Shanxi Medical University Shanxi Bethune Hospital Shanxi Academy of Medical Sciences Tongji Shanxi Hospital  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenwen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feiquan","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengna","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 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