{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:19:08Z","timestamp":1788783548776,"version":"build-2803163510"},"reference-count":210,"publisher":"Wiley","issue":"25","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32500653"],"award-info":[{"award-number":["32500653"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M782596"],"award-info":[{"award-number":["2025M782596"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020084","name":"Guangzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["2024A03J0895"],"award-info":[{"award-number":["2024A03J0895"]}],"id":[{"id":"10.13039\/501100020084","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood. Early immune checkpoint inhibitors have delivered significant clinical benefit, but their efficacy and durability remain limited in many patients. These limitations have driven the exploration of next\u2010generation immune checkpoints and additional regulatory pathways that shape tumor\u2010immune interactions. Recent advances have broadened the immune checkpoint landscape and revealed new targets. These targets operate within interconnected networks shaped by tumor\u2010intrinsic alterations, microenvironmental cues, the microbiome, and neuroimmune crosstalk. The application of emerging technologies has enabled high\u2010resolution dissection of immune\u2010tumor dynamics, providing a technological foundation for improving clinical outcomes through precise patient stratification and intervention. Furthermore, distinct regulated cell deaths, including apoptosis, ferroptosis, pyroptosis, necroptosis, and alkaliptosis, are increasingly recognized as critical modulators of antitumor immunity. Harnessing these mechanisms offers a rational path toward designing targeted and controllable therapeutic strategies that enhance the efficacy and durability of cancer immunotherapy.<\/jats:p>","DOI":"10.1002\/advs.202521355","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T19:07:34Z","timestamp":1775156854000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies"],"prefix":"10.1002","volume":"13","author":[{"given":"Fangquan","family":"Chen","sequence":"first","affiliation":[{"name":"DAMP Laboratory The Third Affiliated Hospital Guangzhou Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiutao","family":"Cai","sequence":"additional","affiliation":[{"name":"DAMP Laboratory The Third Affiliated Hospital Guangzhou Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhao","family":"Lin","sequence":"additional","affiliation":[{"name":"DAMP Laboratory The Third Affiliated Hospital Guangzhou Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruirui","family":"Liang","sequence":"additional","affiliation":[{"name":"DAMP Laboratory The Third Affiliated Hospital Guangzhou Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Surgery UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daolin","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Surgery UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1708-0409","authenticated-orcid":false,"given":"Jiao","family":"Liu","sequence":"additional","affiliation":[{"name":"DAMP Laboratory The Third Affiliated Hospital Guangzhou Medical University  Guangzhou Guangdong China"},{"name":"DAMP Laboratory Department of Critical Care Medicine the Third Affiliated Hospital Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.Can\u201021\u20103917"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz011"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2407417"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.19.00934"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010019\u20100218\u20104"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010025\u201000824\u20109"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010024\u201002068\u20105"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010025\u201004186\u20105"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201009882\u20103"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.03.039"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201065312\u2010y"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.09.029"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102025\u2010336744"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.12.043"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2025.11.006"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102023\u2010007847"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2025.12.005"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010025\u201000879\u20108"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010022\u201000600\u2010w"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010025\u201001061\u20107"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010025\u201000832\u20109"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.2"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010021\u201000552\u20107"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci180282"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018\u2010023\u201000598\u20109"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101456\u20100"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.ade5343"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.03.019"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010023\u201006511\u20109"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018\u2010025\u201000958\u20107"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010023\u201006568\u20106"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010025\u201002233\u20104"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326\u20106066.Cir\u201021\u20100690"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.04.015"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adn4302"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.Ccr\u201025\u20101826"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010024\u201001646\u20102"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2024.285304"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adv5085"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018\u2010023\u201000691\u2010z"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adp4986"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2025.102312"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.Can\u201024\u20101941"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.Ccr\u201022\u20103911"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2024.03.027"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.Ccr\u201024\u20100439"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556\u2010023\u201001185\u2010x"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010025\u201002185\u20109"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.12.023"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001545\u2010x"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010025\u201003746\u2010z"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201055207\u20109"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.Ccr\u201024\u20100499"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2025.03.035"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.02.008"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.04.032"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201009000\u20103"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010025\u201002363\u2010z"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010025\u201002236\u20109"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201009303\u20105"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.01.008"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201009203\u20108"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010024\u201001802\u20103"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.Cd\u201020\u20100672"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23003"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1604958"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.08.069"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.Cd\u201016\u20101223"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adx8134"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201084465\u20106"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13649"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379\u2010019\u20100322\u20109"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201006300\u20103"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.07.034"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201009493\u2010y"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.07.016"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32278"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2014.04.005"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201063659\u2010w"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.06.027"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2025.02.014"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010025\u201003873\u20107"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2025.07.023"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201009574\u2010y"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010025\u201000966\u20103"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adh2334"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2025.07.007"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556\u2010024\u201001372\u20104"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2025.07.013"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2025.07.017"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010025\u201001347\u20101"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.03.015"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2025.07.006"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.12.013"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.08.018"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1282680"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587\u2010023\u201001957\u20108"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.03.002"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201016079\u2010x"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.03.011"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.09.031"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.11.010"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.02.010"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010023\u201006026\u20103"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2025.102306"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422\u2010025\u201001098\u20104"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201008735\u20103"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201009370\u20108"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201009411\u20102"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007767\u20105"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adx9221"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201009434\u20109"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abc8188"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(20)30417\u20107"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.21.02067"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2024.03.005"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco\u201024\u201002239"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(23)00449\u20107"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2402141"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.1588"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.1024"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201005368\u20108"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.01.010"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102022\u2010005301"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33133"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102021\u2010002863"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.Ccr\u201020\u20102886"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.1991.9.4.694"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.Cd\u201019\u20101510"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102024\u2010010777"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102024\u2010010143"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201008305\u2010z"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4394"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2111380"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010024\u201003088\u20102"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(23)00540\u20105"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(21)00149\u20102"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(21)00658\u20106"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2023.0340"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2025.09.007"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.03.030"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201008732\u20106"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2025.03.014"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2013.59"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201005426\u20101"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010024\u201001564\u20103"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101170\u2010y"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2022.02.003"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.04.009"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.12.002"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2022.0202"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.025"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201005443\u20100"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.10.010"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.02.015"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1714209"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.01.090"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2021.2008692"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102020\u2010001369"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201031218\u20102"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15514"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.05.009"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20102079\u20101"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2025.102291"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201055083\u20103"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111553"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.07.036"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aaw2004"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402x.2016.1149673"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.10.014"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature17403"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556\u2010025\u201001740\u20108"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201057583\u20102"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111911"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.12.004"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2021.05.003"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf0529"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.996307"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123201"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202411122"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201081317\u2010x"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adk9167"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.11.002"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.03.018"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010025\u201002193\u20103"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018\u2010024\u201000772\u20107"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010024\u201003398\u20105"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201008378\u2010w"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2025.08.009"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.11.037"},{"key":"e_1_2_12_192_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010024\u201001943\u20105"},{"key":"e_1_2_12_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.04.011"},{"key":"e_1_2_12_194_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422\u2010019\u20100164\u20105"},{"key":"e_1_2_12_195_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf1292"},{"key":"e_1_2_12_196_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.ade6256"},{"key":"e_1_2_12_197_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.adh2456"},{"key":"e_1_2_12_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.08.007"},{"key":"e_1_2_12_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1074\u20107613(00)00031\u20105"},{"key":"e_1_2_12_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2018.02.010"},{"key":"e_1_2_12_201_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010023\u201001569\u2010z"},{"key":"e_1_2_12_202_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201003626\u20109"},{"key":"e_1_2_12_203_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935\u2010023\u201003116\u20100"},{"key":"e_1_2_12_204_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010026\u201002471\u20100"},{"key":"e_1_2_12_205_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018\u2010025\u201001038\u20106"},{"key":"e_1_2_12_206_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adm7269"},{"key":"e_1_2_12_207_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.2895"},{"key":"e_1_2_12_208_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan4236"},{"key":"e_1_2_12_209_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010020\u201002231\u20100"},{"key":"e_1_2_12_210_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010024\u201001037\u20104"},{"key":"e_1_2_12_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2025.09.003"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202521355","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202521355","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202521355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:45:31Z","timestamp":1777884331000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202521355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,2]]},"references-count":210,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/advs.202521355"],"URL":"https:\/\/doi.org\/10.1002\/advs.202521355","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,2]]},"assertion":[{"value":"2025-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e21355"}}