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The aggregation of amyloid\u2010beta (A\u03b2) peptides into oligomers and fibrils is central to its pathogenesis. While oligomers represent the most neurotoxic species, larger aggregates serve as reservoirs, maintaining pathological A\u03b2 levels. To our knowledge, this study is the first to investigate Boron Neutron Capture Therapy (BNCT) as a method to selectively destabilize A\u03b2 aggregates. This is achieved by inducing structural modifications in the A\u03b2 peptide, aiming to convert fibrils into innocuous species. The approach utilizes\n                    <jats:sup>10<\/jats:sup>\n                    B\u2010enriched monocarbonyl analogs of curcumin (BMACs), a novel molecule that binds to A\u03b2 fibrils and enables the site\u2010specific release of high\u2010linear\u2010energy\u2010transfer (LET) \u03b1 particles and lithium ions upon neutron exposure. In vitro, A\u03b2 aggregates were characterized using FESEM and Thioflavin T staining. The binding affinities of BMACs were determined through competition assays, with inhibition constants calculated using the Cheng\u2010Prusoff equation. Post\u2010irradiation analysis by\n                    <jats:sup>1<\/jats:sup>\n                    H\u2010NMR and mass spectrometry demonstrated selective oxidation of histidine residues, a chemical modification capable of inducing fibril destabilization. This study provides proof of concept that not only offers future perspectives for Alzheimer's treatment but also enhances the understanding of radiation effects on proteins, particularly within the context of amyloidosis.\n                  <\/jats:p>","DOI":"10.1002\/advs.202521701","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:18:32Z","timestamp":1776399512000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Carboranyl\u2010Curcuminoids for the Neutron Capture\u2010Based Treatment of Amyloid Aggregates in Alzheimer's Disease"],"prefix":"10.1002","volume":"13","author":[{"given":"Sebastiano","family":"Micocci","sequence":"first","affiliation":[{"name":"Department of Molecular Biotechnology and Health Sciences University of Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Parisotto","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4842-1109","authenticated-orcid":false,"given":"Diego","family":"Alberti","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology and Health Sciences University of Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Lanfranco","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Bitonto","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology and Health Sciences University of Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1326-8183","authenticated-orcid":false,"given":"Polyssena","family":"Renzi","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Salmi","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Magnani","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology and Health Sciences University of Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0726-3025","authenticated-orcid":false,"given":"Federica Dal","family":"Bello","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology and Health Sciences University of Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katiuscia","family":"Pagano","sequence":"additional","affiliation":[{"name":"Istituto Di Scienze e Tecnologie Chimiche \"Giulio Natta\" (SCITEC) National Council of Research (CNR)  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Ragona","sequence":"additional","affiliation":[{"name":"Istituto Di Scienze e Tecnologie Chimiche \"Giulio Natta\" (SCITEC) National Council of Research (CNR)  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2415-128X","authenticated-orcid":false,"given":"Nicoletta","family":"Protti","sequence":"additional","affiliation":[{"name":"Department of Physics \u201cA. Volta\u201d University of Pavia  Pavia Italy"},{"name":"Nuclear Physics National Institute (INFN) Pavia Unit  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2622-2798","authenticated-orcid":false,"given":"Annamaria","family":"Deagostino","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2998-5424","authenticated-orcid":false,"given":"Simonetta","family":"Geninatti Crich","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology and Health Sciences University of Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1132814"},{"key":"e_1_2_9_3_1","first-page":"1","volume-title":"Secondary \"World Alzheimer Report 2023: Reducing dementia risk: Never Too Early, Never Too Late\"","author":"Long S.","year":"2023"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202400277"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2014.09.004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.04.017"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.762526"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.2.567"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.16213"},{"key":"e_1_2_9_10_1","first-page":"5","article-title":"Amyloid\u2010beta Alzheimer Targets\u2014Protein Processing, Lipid Rafts, and Amyloid\u2010beta Pores","volume":"89","author":"Arbor S. 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