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However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation requirements. Here, we report the development of a self\u2010healing colloidal gelatin hydrogel engineered as a flowable hemostatic matrix and successfully demonstrate its bench\u2010to\u2010bedside translation into a biomedical device (Colloidose). Specifically, amphoteric gelatin sub\u2010microparticles self\u2010assemble into an integrated gel network exhibiting a high storage modulus (G\u2019 &gt; 15\u00a0kPa) and a healing efficiency exceeding 95%, enabling rapid in situ solidification to accelerate blood clot formation. By benchmarking against conventional flowable matrices composed of coarse hundreds of micrometer\u2010sized gelatin granules, we demonstrate that Colloidose offers superior hemostatic efficacy in anatomically challenging or pressure\u2010intolerant sites (e.g., hepatobiliary, otorhinolaryngological, and gynecologic surgeries). Supported by comprehensive preclinical studies and over 300 clinical cases, Colloidose exemplifies the successful translation of an advanced self\u2010healing biomaterial, establishing its role as a next\u2010generation hemostat and opening new avenues for injectable and moldable biomedical devices.<\/jats:p>","DOI":"10.1002\/advs.202521713","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:12:44Z","timestamp":1777475564000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bench\u2010to\u2010Bedside Translation of Self\u2010Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials"],"prefix":"10.1002","volume":"13","author":[{"given":"Ganjun","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery and Orthopedic Research Institute &amp; West China Hospital 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