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However, the precise mechanisms underlying the regulation of differentiation remain unclear. This study investigated the role of the transcriptional regulator Zinc Finger Matrin\u2010Type 1 (\n                    <jats:italic>Zmat1<\/jats:italic>\n                    ) in both osteoclastogenesis and osteoblastogenesis.\n                    <jats:italic>Zmat1<\/jats:italic>\n                    deficiency resulted in decreased osteoclast activity, and bone resorption. Mechanistically, ZMAT1 was significantly upregulated during osteoclast differentiation and acted as a transcriptional repressor of the E3 ubiquitin ligase TRIM46, which regulates YAP1 degradation via K48\u2010linked ubiquitination. Furthermore,\n                    <jats:italic>Zmat1<\/jats:italic>\n                    deficiency enhanced osteoblast activity and bone formation. These findings highlight a novel ZMAT1\/TRIM46\/YAP1 axis, providing new insights into the transcriptional regulation of both osteoclast and osteoblast differentiation, and present potential therapeutic targets for osteoporosis.\n                  <\/jats:p>","DOI":"10.1002\/advs.202521783","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:58:15Z","timestamp":1772967495000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["ZMAT1 Promotes Osteoclastogenesis Through TRIM46 Mediated YAP1 Degradation and Inhibits Osteoblastogenesis"],"prefix":"10.1002","volume":"13","author":[{"given":"Xinyu","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Traumatic Orthopedics Changhai Hospital Second Military Medical University  Shanghai 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