{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T19:56:08Z","timestamp":1793476568468,"version":"4.5.0"},"reference-count":62,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2024NSCQ\u2010MSX0394"],"award-info":[{"award-number":["CSTB2024NSCQ\u2010MSX0394"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Sepsis\u2010associated acute kidney injury (SAKI) remains a life\u2010threatening condition with limited therapeutic options, primarily driven by rampant oxidative stress, inflammatory dysregulation. Importantly, aberrant formation of neutrophil extracellular traps (NETs) and sustained innate immune activation further exacerbate renal injury, highlighting the need for strategies that precisely modulate these intertwined pathological mechanisms. Here, we present neutrophil\u2010mimetic nanoscavengers (MD@NM) that comprise a catalytic core of DNase\u20101\u2010loaded Mn\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    nanozymes enveloped by a neutrophil membrane engineered to actively target and simultaneously disrupt multiple pathological circuits in SAKI. The neutrophil membrane confers chemokine\u2010receptor (e.g., CXCR2) mediated homing to injured kidneys, while the Mn\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    nanozymes catalytically scavenge ROS and the loaded DNase\u20101 enzymatically degrades NETs\u2010derived extracellular DNA, thereby suppressing the cGAS\u2010STING pathway and skewing macrophage polarization toward an M2 reparative phenotype. In a murine model of LPS\u2010induced SAKI, MD@NM treatment facilitated robust renal targeting, attenuated neutrophilic infiltration, resolved cytokine storm, and ameliorated structural kidney damage. Collectively, this biomimetic platform represents a novel strategy for precision immunomodulation and multi\u2010mechanistic therapy against SAKI by integrating antioxidative, NETs\u2010scavenging, and anti\u2010inflammatory functions into a single nanotherapeutic agent.\n                  <\/jats:p>","DOI":"10.1002\/advs.202521861","type":"journal-article","created":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T11:39:50Z","timestamp":1771155590000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Neutrophil\u2010Mimetic Nanoscavengers Target the Inflammatory Microenvironment to Eliminate NETs\/ROS and Immunomodulate cGAS\u2010STING Signaling in Septic AKI"],"prefix":"10.1002","volume":"13","author":[{"given":"Zening","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital of Chongqing Medical University  Chongqing 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