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To address this, this study develops a bionic magnesium alloy internal fixation coating inspired by the \u201cbrick\u2010and\u2010mortar\u201d structure of pearl, aiming to improve bone\u2010implant integration and vascularization in osteoporotic conditions. The multifunctional coating consists of a calcium phosphate (Ca\u2010P) \u201cbrick\u201d layer, which serves as a mineralization template and corrosion barrier, and fibronectin\u2010mimetic peptides (Fn\u2010mimetic peptides) as the \u201cmortar\u201d to promote cell adhesion, regulate immune responses, and stimulate angiogenesis. This bionic multilayer structure not only alleviates oxidative stress in the osteoporotic microenvironment but also fosters immune regulation\u2010osteogenesis coupling and improves the bone\u2010vascular\u2010immune microenvironment. It precisely controls the degradation rate of Mg alloys and enhances tissue repair. The CaP layer reduces rapid degradation and prevents hydrogen gas release and local alkalinization, whereas Fn\u2010mimetic peptides enhance early bone integration and vascularization. The synergistic effect of the magnesium alloy implant and bionic coating significantly improved bone implant stability, regeneration, and vascularization, as demonstrated in osteoporotic rat models, offering a promising strategy for the design of bone repair materials under pathological conditions.<\/jats:p>","DOI":"10.1002\/advs.202521927","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T16:40:38Z","timestamp":1766248838000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pearl\u2010Like Bioinspired Coating Enables Regulation of Mg Degradation for Osteoporotic Bone Repair"],"prefix":"10.1002","volume":"13","author":[{"given":"Siming","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics The Second Affiliated Hospital of Anhui University of Chinese Medicine  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Kourkoumelis","sequence":"additional","affiliation":[{"name":"Department of Medical Physics University of Ioannina Ioannina 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USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics The Second Affiliated Hospital of Anhui University of Chinese Medicine  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division 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