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Whether cryoablation is superior to thermal ablation in the era of immunotherapy and the related mechanism remains undefined. We first observed superior progression\u2010free survival with cryoablation compared with thermal ablation in patients with oligoresidual\u00a0disease after immunotherapy. Single\u2010cell RNA sequencing of human peripheral blood monocyte cells and mouse tumors showed that cryoablation combined with anti\u2010PD\u20101 expanded more CXCL10\n                    <jats:sup>+<\/jats:sup>\n                    macrophages than thermal ablation combination. CXCR3 blockade and inhibition of T cells egressing from draining lymph nodes abolished the systemic anti\u2010tumor efficacy. Mechanistically, tumor DNA released by cryoablation was taken up by macrophages, activating the cGAS\u2013STING signaling pathway, increasing the pool of CXCL10\n                    <jats:sup>+<\/jats:sup>\n                    macrophages and CXCL10 secretion. Our study demonstrated that CXCL10\n                    <jats:sup>+<\/jats:sup>\n                    macrophages and the CXCR3\n                    <jats:sup>+<\/jats:sup>\n                    T cells were critical mediators of the systemic anti\u2010tumor immunity induced by cryoablation in advanced NSCLC.\n                  <\/jats:p>","DOI":"10.1002\/advs.202521931","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T19:24:41Z","timestamp":1773343481000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cryoablation Activates the cGAS\u2013STING\u2010CXCL10 Axis in Macrophages to Enhance Anti\u2010Tumor Immunity in NSCLC"],"prefix":"10.1002","volume":"13","author":[{"given":"Xinxin","family":"Zhi","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Shanghai Pulmonary Hospital, School of Medicine Tongji University  Shanghai 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