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Among them, nitric oxide (NO) has emerged as a central player. Recent advancements have transitioned from conventional donor\u2010based systems with limited control over dose and localization to wearable gas\u2010delivery platforms capable of real\u2010time, patient\u2010specific dosing and frequently coupling with embedded diagnostic functionalities for dynamic feedback and precision control. Importantly, the therapeutic scope of gas biology is expanding beyond NO to encompass other clinically relevant and emerging gases, including O\n                    <jats:sub>2<\/jats:sub>\n                    , CO, H\n                    <jats:sub>2<\/jats:sub>\n                    S, H\n                    <jats:sub>2<\/jats:sub>\n                    , CO\n                    <jats:sub>2<\/jats:sub>\n                    , SO\n                    <jats:sub>2<\/jats:sub>\n                    , and Xe. These gases exhibit multifaceted biological effects ranging from cytoprotection and vasoregulation to antimicrobial and anti\u2010inflammatory actions, thereby necessitating innovative material\u2010based and bioresponsive delivery strategies that can interface dynamically with biological systems. By critically assessing progress in material platforms, responsive release mechanisms, and multimodal delivery approaches, this review bridges fundamental gas biology with clinically translatable therapeutic design. We further highlight persistent translational bottlenecks, such as dose control, off\u2010target effects, and long\u2010term safety, while outlining emerging research pathways poised to define the next era of gas\u2010based medicine.\n                  <\/jats:p>","DOI":"10.1002\/advs.202521942","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T08:13:36Z","timestamp":1773994416000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond"],"prefix":"10.1002","volume":"13","author":[{"given":"Syed Muntazir","family":"Andrabi","sequence":"first","affiliation":[{"name":"Department of Surgery\u2010Transplant and Mary and Dick Holland Regenerative Medicine Program University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navatha Shree","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Surgery\u2010Transplant and Mary and Dick Holland Regenerative Medicine Program University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran Ibn Gani","family":"Rather","sequence":"additional","affiliation":[{"name":"Department of Surgery\u2010Transplant and Mary and Dick Holland Regenerative Medicine Program University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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