{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T02:19:57Z","timestamp":1788142797631,"version":"build-2803163510"},"reference-count":85,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202208080154"],"award-info":[{"award-number":["202208080154"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hormone\u2010producing cells in the pancreas and intestine regulate whole\u2010body metabolism and are dysregulated in obesity and diabetes. A deeper understanding of endocrine lineage formation (endocrinogenesis) in these organs is essential to elucidate the healthy state and disease trajectories. Here, we performed cross\u2010species (mouse and human) and cross\u2010system (in vivo and in vitro) comparisons of pancreatic endocrine progenitors (EPs), complemented by cross\u2010organ (pancreas and intestine) analyses, using single\u2010cell transcriptomics and epigenomics, together with mouse bulk proteomics. We uncovered conserved and distinct gene regulatory networks (GRNs) and cell\u2010cell communication patterns during lineage allocation across species, systems, and organs. Additionally, we identified diabetes\u2010associated genes restricted to embryonic pancreatic EPs but largely absent in the adult pancreas, suggesting that dysregulation during development may predispose to diabetes. Furthermore, our multi\u2010source EP profiling resolved the transcriptional programs underlying the aberrant, in vitro\u2010enriched enterochromaffin cell formation during differentiation toward human islet cells, suggesting that these cells may not correspond to a naturally occurring cell type present in vivo development. Finally, we revealed conserved, dynamic shifts in the cell cycle and cytoskeletal organization, alongside divergent mRNA translation, during endocrinogenesis. Collectively, this multi\u2010source EP profiling establishes a resource mapping the molecular landscape of endocrinogenesis across two major metabolic\u2010endocrine organs.<\/jats:p>","DOI":"10.1002\/advs.202522011","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T02:06:15Z","timestamp":1788141975000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Charting Endocrine Progenitors Across Species and Organs"],"prefix":"10.1002","author":[{"given":"Changying","family":"Jing","sequence":"first","affiliation":[{"name":"Institute of Diabetes and Regeneration Research Helmholtz Munich  Neuherberg Germany"},{"name":"German Center for Diabetes Research (DZD)  Neuherberg Germany"},{"name":"Munich Medical Research School (MMRS) Ludwig Maximilian University (LMU)  Munich 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