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Biological Pacinian corpuscles transduce mechanical stimuli into localized strain via concentric lamellar architecture, enabling subtle and dynamic perception of pressure fluctuations. Inspired by the working mode of Pacinian corpuscles, this work presents a piezoelectric tactile sensor featuring a multilayer grooved architecture that transduces external pressure into localized in\u2010plane strain within the piezoelectric layer, effectively enhancing dipole alignment and charge separation. Finite element simulations and experimental results confirm that the grooved architecture contributes to strain concentration, giving rise to an ultrahigh sensitivity of 185 mV\u00b7kPa\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>1<\/jats:sup>\n                    and linear electromechanical response up to 300 kPa and a power density of 806 \u00b5W\u00b7cm\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>2<\/jats:sup>\n                    . The tactile sensor enables high\u2010fidelity acquisition of multi\u2010site pulse waveforms and accurate estimation of blood pressure, facilitating comprehensive cardiovascular assessment via heart rate variability and Poincare analysis. This bioinspired design offers an effective approach to overcoming the intrinsic limitations of piezoelectric materials and holds significant potential for developing high\u2010performance piezoelectric sensors for continuous, noninvasive health monitoring.\n                  <\/jats:p>","DOI":"10.1002\/advs.202522157","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T14:18:06Z","timestamp":1770128286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pacinian Corpuscle\u2010Inspired Strain Conversion Enables Ultrasensitive, Linear, and Broad\u2010Range Piezoelectric Sensing for Cardiovascular Health Monitoring"],"prefix":"10.1002","volume":"13","author":[{"given":"Qi","family":"Yang","sequence":"first","affiliation":[{"name":"Center for Advanced Analytical Science c\/o School of Chemistry and Chemical Engineering Guangzhou University  Guangzhou P. R. 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