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Herein, we mapped the sciatic\u2010nerve endothelium and identified angiogenic ECs (AECs) as the dominant pre\u2010regenerative subset triggered by injury. However, the molecular circuitry governing AEC\u2010mediated regeneration awaits elucidation. Unexpectedly, we found that antler blood, routinely discarded during velvet antler harvesting, contains potent regenerative cues that strongly boost endothelial\u2010driven repair. By integrating a single\u2010cell atlas of antler with the proteomics of antler blood\u2013derived exosomes (AB\u2010EXO), we traced the vesicles to their cellular origins and demonstrated that AB\u2010EXO encapsulate the antler's potent regenerative signature. Further mechanistic interrogation showed that AB\u2010EXO induced pro\u2010angiogenic phenotypes in ECs via the upregulation of IMP U3 small nucleolar ribonucleoprotein 3 (IMP3). Overlaying IMP3 expression onto our EC atlas pinpointed IMP3\u2010high AECs (IMP3+AECs) as the pivotal vascular drivers of nerve repair. Ultimately, our findings establish IMP3+AECs as the critical component of the pre\u2010regenerative EC atlas within the peripheral nerve and position AB\u2010EXO as an effective therapy for nerve repair.<\/jats:p>","DOI":"10.1002\/advs.202522170","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:37:21Z","timestamp":1787845041000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pre\u2010Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair"],"prefix":"10.1002","author":[{"given":"Jinsheng","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Zhengzhou University Zhengzhou University  Zhengzhou China"},{"name":"Department of Sports Medicine of the Second Affiliated Hospital and Liangzhu Laboratory Zhejiang University School of Medicine  Hangzhou 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