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To address these challenges, we developed an amphiphilic peptide dendrimer\u2010based multifunctional drug delivery system for integrating photothermal therapy (PTT), chemotherapy, and immunogenic cell death (ICD) to overcome the limitations of single\u2010modality treatments. Efficient drug delivery via the nanoplatform is realized through improving circulation stability, facilitating accumulation and penetration in tumor tissues, promoting cellular uptake, and accelerating tumor microenvironment\u2010responsive drug release. The mitochondria\u2010targeting property is derived from a mitochondria\u2010specific photothermal agent and a lipophilic cationic structure in the amphiphilic dendrimer, and it allows selective mitochondrial accumulation and disruption of the mitochondrial function. In vivo and in vitro studies confirm that PTT synergizes with chemotherapy to significantly enhance therapeutic efficacy, effectively induce ICD to modulate the tumor microenvironment, and strengthen antitumor responses. This nanoplatform enhances drug delivery, induces mitochondrial dysfunction, and achieves potent therapeutic effects, therefore, it could be fine\u2010tuned to become versatile for combination cancer therapies.<\/jats:p>","DOI":"10.1002\/advs.202522226","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:17:10Z","timestamp":1772957830000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Mitochondria\u2010Specific Nanomedicine for Synergistic Chemo\u2010Photothermal Therapy and Immunogenic Activation Against Breast Cancer"],"prefix":"10.1002","volume":"13","author":[{"given":"Min","family":"Li","sequence":"first","affiliation":[{"name":"Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research School of Pharmacy Fujian Medical University  Fuzhou 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