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Organic tissue\u2010like nanomaterials built from foldamer peptidomimetics and natural biomolecules could expand our boundaries toward new biocompounds that are able to address global health challenges. Related, antimicrobial resistance against conventional antibiotics motivates search for new compounds with orthogonal mechanisms. Here we designed an antibacterial system where natural adenosine phosphates (APs) trigger supramolecular co\u2010assemblies from a lipopolysaccharide\u2010targeting (LPS) antimicrobial \u03b2\n                    <jats:sup>3<\/jats:sup>\n                    \u2010peptide (3K). Cryo\u2010EM and confocal microscopy images on\n                    <jats:italic>E. coli<\/jats:italic>\n                    confirmed that real\u2010time action of 3K\u2010APs progresses via a multiscale mechanism. Initially, entangled nanofibers capture bacteria resulting in agglutination. Further, individual cells become enwrapped, undergoing a reduction in cell height, as observed by AFM. Finally, in situ cryo\u2010EM observations, offering insight into their structural state in solution, suggest an association between the presence of extracellular vesicles and loss of cell integrity, which may contribute to cell death. 3K\u2010ATP was tested on multidrug resistant bacterial strains which adapted to membrane\u2010targeting antibiotics, where only limited cross\u2010resistance was observed. Resistant strains modifying their LPS even showed increased sensitivity. Besides induced disassembly by target membranes, degradation could also be reached through enzymatic hydrolysis of APs, altogether resulting in supramolecular bactericides with controllable build\u2010up and clearance.\n                  <\/jats:p>","DOI":"10.1002\/advs.202522269","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T08:29:14Z","timestamp":1773908954000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An ATP\u2010Mediated Antibiotic \u03b2\u2010Peptide Nanofiber That Kills Multidrug\u2010Resistant Bacteria via a Multistage Mechanism"],"prefix":"10.1002","volume":"13","author":[{"given":"Sohini","family":"Chakraborty","sequence":"first","affiliation":[{"name":"Institute of Materials and Environmental Chemistry HUN\u2010REN Research Centre for Natural Sciences  Budapest Hungary"},{"name":"Department of Chemistry, Stella Maris College (Autonomous) University of Madras  Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"el Battioui","sequence":"additional","affiliation":[{"name":"Institute of Materials and Environmental Chemistry HUN\u2010REN Research Centre for Natural Sciences  Budapest Hungary"},{"name":"Hevesy Gy\u00f6rgy Ph.D. School of Chemistry E\u00f6tv\u00f6s Lor\u00e1nd University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e1niel","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"Institute of Molecular Life Sciences HUN\u2010REN Research Centre for Natural Sciences  Budapest Hungary"},{"name":"Doctoral School of Biology and Institute of Biology E\u00f6tv\u00f6s Lor\u00e1nd University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1lint","family":"Jezs\u00f3","sequence":"additional","affiliation":[{"name":"Institute of Materials and Environmental Chemistry HUN\u2010REN Research Centre for Natural Sciences  Budapest Hungary"},{"name":"HUN\u2010REN\u2010ELTE Motor Pharmacology Research Group, Department of Biochemistry E\u00f6tv\u00f6s Lor\u00e1nd University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lejla","family":"Daruka","sequence":"additional","affiliation":[{"name":"Synthetic and Systems Biology Unit Institute of Biochemistry HUN\u2010REN Biological Research Centre Szeged  Szeged H\u20106726 Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasvilla","family":"Sonallya","sequence":"additional","affiliation":[{"name":"Institute of Materials and Environmental Chemistry HUN\u2010REN Research Centre for Natural Sciences  Budapest Hungary"},{"name":"Hevesy Gy\u00f6rgy Ph.D. School of Chemistry E\u00f6tv\u00f6s Lor\u00e1nd University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00fcnde","family":"Juh\u00e1sz","sequence":"additional","affiliation":[{"name":"Institute of Materials and Environmental Chemistry HUN\u2010REN Research Centre for Natural Sciences  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Hirmond\u00f3","sequence":"additional","affiliation":[{"name":"Institute of Molecular Life Sciences HUN\u2010REN Research Centre for Natural Sciences  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imola","family":"Cs. 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