{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:00:52Z","timestamp":1790769652901,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Current diagnostic approaches for head and neck cancer rely primarily on white\u2010light endoscopy and tissue biopsy, providing only static, episodic assessments that fail to capture dynamic changes in tumor biology over time. The absence of continuous, detailed molecular and microscopic structural information makes early identification of dysplasia or cancer difficult and can delay critical treatment. Here, we introduce a unified, label\u2010free endoscopic platform that combines Raman spectroscopy (RS) and optical coherence tomography (OCT) within a miniaturized, forward\u2010viewing fiber\u2010optic probe. This integration enables simultaneous video\u2010rate OCT imaging and 1 s RS acquisition, linking morphological and molecular tissue trajectories in vivo. We developed an explainable AI\u2010based fusion framework that learns joint temporal representations of biochemical and structural features to classify tissue states while highlighting the most influential predictors. In a longitudinal 4NQO\u2010induced murine model of carcinogenesis, the system tracked epithelial transformation from hyperplasia through dysplasia and carcinoma in situ to invasive cancer. OCT provides the dominant structural contrast in this thin\u2010epithelium murine model, while RS adds complementary molecular specificity. By capturing temporally resolved morphological and molecular trajectories in vivo, this platform demonstrates a new approach for early cancer detection and has potential to support surveillance and clinical decision\u2010making.<\/jats:p>","DOI":"10.1002\/advs.202522344","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:29:29Z","timestamp":1790767769000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Morphomolecular Monitoring of Head and Neck Carcinogenesis"],"prefix":"10.1002","author":[{"given":"Jianrong","family":"Qiu","sequence":"first","affiliation":[{"name":"Centre for Craniofacial &amp; Regenerative Biology King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka G.","family":"Bhosale","sequence":"additional","affiliation":[{"name":"Centre for Craniofacial &amp; Regenerative Biology King's College London  London UK"},{"name":"Department of Haematology University College London Cancer Institute  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Kumar","sequence":"additional","affiliation":[{"name":"Centre for Craniofacial &amp; Regenerative Biology King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeyrroy","family":"Gabriel","sequence":"additional","affiliation":[{"name":"CGRM, BMBS, Guy's Campus King's College London  London UK"},{"name":"St. John's Histopathology Tissue Sciences Synnovis Analytics St. Thomas\u2019 Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyue","family":"Liu","sequence":"additional","affiliation":[{"name":"Centre for Craniofacial &amp; Regenerative Biology King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciro","family":"Chiappini","sequence":"additional","affiliation":[{"name":"Centre for Craniofacial &amp; Regenerative Biology King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Cook","sequence":"additional","affiliation":[{"name":"Centre For Oral Clinical and Translational Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3986-8942","authenticated-orcid":false,"given":"Mads S.","family":"Bergholt","sequence":"additional","affiliation":[{"name":"Centre for Craniofacial &amp; Regenerative Biology King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/205016841600500112"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2017.888"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147\u2010010\u20100157\u20103"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3233\/cbm\u20102011\u20100163"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.Cd\u201012\u20100537"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201019401\u20109"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379\u2010022\u201001067\u2010x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.11.002"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.8.000524"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1376"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1364\/boe.449110"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ado9721"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1364\/OPTICA.4.000496"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23139"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphy.2020.616618"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.26.8.080601"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/15599612.2025.2585610"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216\u2010015\u20108800\u20105"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2022.3763"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.41.003045"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.21041"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphot.2022.929574"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.16536"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202302962"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.4c06014"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.1c02178"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.2c04743"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202522344","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202522344","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202522344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:29:30Z","timestamp":1790767770000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202522344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":28,"alternative-id":["10.1002\/advs.202522344"],"URL":"https:\/\/doi.org\/10.1002\/advs.202522344","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"2025-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22344"}}