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Within CNB\u2010ePRP, the CNB consists of polydopamine nanobottle loaded with thrombin, personalized drugs and a phase\u2010change material. As a photothermal agent and dual\u2010stage controller, CNB not only enables in situ PRP activation at physiological temperature to slowly release various growth factors (GFs) via thermal\u2010triggered thrombin release, avoiding premature burst release of GFs, but also accelerates the release of GFs from the CNB\u2010ePRP hydrogel through mild photothermal heating under 808\u00a0nm laser irradiation. Meanwhile, SA enhances hydrogel stability and prolongs GF release kinetics. Consequently, CNB\u2010ePRP achieves on\u2010demand delivery of GFs, significantly promoting angiogenesis, cell proliferation and M2 macrophage polarization. Moreover, CNB\u2010ePRP can mitigate oxidative stress via the antioxidant activity of CNB. Furthermore, vancomycin is loaded into CNB to construct a multimodal antimicrobial hydrogel (VCNB\u2010ePRP) that combines antibiotic and photothermal therapy to efficiently eradicate MRSA and promote healing in MRSA\u2010infected diabetic mouse wounds. Collectively, this study offers a smart PRP\u2010derived platform, characterized by in situ PRP activation, on\u2010demand GFs release, personalized antimicrobial loading and multifunctional therapy, for managing diabetic wounds with great translational potential.<\/jats:p>","DOI":"10.1002\/advs.202522427","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:26:17Z","timestamp":1773005177000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Photothermal\u2010Responsive PRP\u2010Loaded Hydrogel Engineered With Composite Nanobottle for Controllable Delivery of Growth Factors and Multifunctional Therapy of Diabetic Wounds"],"prefix":"10.1002","volume":"13","author":[{"given":"Wen\u2010Qiang","family":"Qu","sequence":"first","affiliation":[{"name":"Department of Orthopedic Trauma and Microsurgery Zhongnan Hospital of Wuhan University  Wuhan P. R. 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