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Here, methyltransferase\u2010like 3 (METTL3) mediated N\n                    <jats:sup>6<\/jats:sup>\n                    \u2010methyladenosine (m\n                    <jats:sup>6<\/jats:sup>\n                    A) modification is identified as a central driver of thyroid inflammation. METTL3 expression and m\n                    <jats:sup>6<\/jats:sup>\n                    A levels were markedly increased in TFCs from AIT patients and EAT mice, and are positively associated with immune inflammation scores. Genetic or pharmacological inhibition of METTL3 suppressed the KDR (kinase insert domain receptor, also known as vascular endothelial growth factor receptor 2, VEGFR2)\/VEGFA signaling loop, reduced inflammatory cytokine release and lymphocyte infiltration, restored Th17\/Treg homeostasis, and alleviated thyroid injury. Mechanistically, ROS promoted METTL3 transcription through inhibition of SIRT1\u2010dependent epigenetic repression, while METTL3\u2010mediated m6A modification stabilized KDR mRNA in a YTHDC2\u2010dependent manner. In turn, activated KDR established an autocrine\u2010paracrine KDR\/VEGFA amplification circuit that sustained inflammatory signaling. Together, these findings uncover the METTL3\u2010KDR axis as a critical epitranscriptomic mechanism driving chronic thyroid inflammation and nominate it as a promising therapeutic target for AIT.\n                  <\/jats:p>","DOI":"10.1002\/advs.202522453","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:48:33Z","timestamp":1782211713000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting METTL3 Attenuates Thyroid Inflammatory Injury by Restoring Th17\/Treg Balance through a YTHDC2\u2010m6A\u2010Dependent KDR\/VEGFA Loop"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8737-3392","authenticated-orcid":false,"given":"Qingyi","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Breast and Thyroid Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 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