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Herein, we report a deep\u2010red light\u2010triggered NO\u2010releasing molecule (DBTBT\u2010NO) via a novel photoexcitation\u2010mediated electron transfer process to induce abundant peroxynitrite generation. The DBTBT\u2010NO can be activated by deep\u2010red light to release NO, which is facilitated by photoinduced intramolecular charge separation. Meanwhile, superoxide anions generated during photolysis rapidly react with NO to produce massive peroxynitrite in mitochondria, which induces tumor cell pyroptosis at a low light dose of 15 J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    and a low concentration of 0.4 \u00b5\n                    <jats:sc>m<\/jats:sc>\n                    . The robust pyroptosis triggered by DBTBT\u2010NO effectively inhibits tumor growth and metastasis in mice with excellent biosafety. This is the first report on boosting peroxynitrite generation through long\u2010wavelength photolysis of benzisothiadiazole\u2010based\n                    <jats:italic>N<\/jats:italic>\n                    \u2010nitrosanilines via a distinct mechanism. This work provides a new approach to fabricate unimolecular peroxynitrite photoinitiators with high pyroptosis induction efficiency, facilitating simplified and improved photoimmunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/advs.202522486","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T14:44:37Z","timestamp":1779720277000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Light\u2010Activatable Nitric Oxide Release via Intramolecular Electron Transfer for Tumor Pyroptosis Induction"],"prefix":"10.1002","volume":"13","author":[{"given":"Chuangxin","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Shanxi University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruipeng","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Shanxi University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxia","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Shanxi University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0317-3455","authenticated-orcid":false,"given":"Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Shanxi University  Taiyuan China"},{"name":"Future Organic Optoelectronics Research Center Global Institute of Future Technology Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liheng","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Shanxi University  Taiyuan 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