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The accumulation of senescent cells is strongly linked to the degeneration of spinal tissues and back pain. Here, we show that administration of the senolytic agents, o\u2010vanillin and RG\u20107112, prevents the development of pain\u2010related behavior in\n                    <jats:italic>\n                      sparc\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice. Treated mice exhibit a reduced expression of senescence markers in the intervertebral discs, vertebral endplates, vertebral bone, and spinal cord, alongside a dampening of pro\u2010inflammatory senescence\u2010associated secretory factors in these tissues. Early senolytic intervention also preserved intervertebral disc volume and vertebral bone microarchitecture, indicating protection against structural spine degeneration. 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