{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:04:09Z","timestamp":1790183049557,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFB3203800"],"award-info":[{"award-number":["2022YFB3203800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Periodontitis is a chronic inflammatory disease primarily driven by pathogenic biofilms, and affects more than 90% of the global population. The increasing prevalence of bacterial resistance, coupled with the protective nature of resilient biofilms, makes it challenging to achieve satisfactory therapeutic outcomes. In this study, an organic small molecule\u2010based photothermal reagent (\n                    <jats:bold>FNP<\/jats:bold>\n                    ) with excellent photothermal property is designed by rational tailor of donor\u2010acceptor combinations, and a supramolecular nucleoside hydrogel (\n                    <jats:bold>ZBAg<\/jats:bold>\n                    ) is developed via silver ion\u2010stabilized base pairing and dynamic boronate ester bonds. The\n                    <jats:bold>ZBAg<\/jats:bold>\n                    hydrogel exhibits a unique coordination mechanism distinct from the traditional intermolecular\n                    <jats:italic>i<\/jats:italic>\n                    \u2010motif coordination mode. The\n                    <jats:bold>ZBAg@FNP<\/jats:bold>\n                    hydrogel is prepared by encapsulating\n                    <jats:bold>FNP<\/jats:bold>\n                    within\n                    <jats:bold>ZBAg<\/jats:bold>\n                    hydrogel, which demonstrates excellent biocompatibility and achieves controlled Ag\n                    <jats:sup>+<\/jats:sup>\n                    release triggered by localized hyperthermia. The\n                    <jats:bold>ZBAg@FNP<\/jats:bold>\n                    hydrogel can damage biofilm structure through photothermal therapy and then improves the penetration of Ag\n                    <jats:sup>+<\/jats:sup>\n                    into the biofilms, resulting in synergistic eradication of the biofilms of oral pathogenic bacteria (\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    and\n                    <jats:italic>Streptococcus mutans<\/jats:italic>\n                    ).\n                    <jats:bold>ZBAg@FNP<\/jats:bold>\n                    hydrogel treatment significantly reduces the levels of proinflammatory cytokines, increases the levels of anti\u2010inflammatory cytokines, and reduces alveolar resorption in periodontitis of rats. This study provides a new strategy for treating periodontitis, and offers insights into the design of antibiofilm materials.\n                  <\/jats:p>","DOI":"10.1002\/advs.202522853","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T17:02:09Z","timestamp":1766250129000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Nucleoside\u2010Based Hydrogel Platform Synergizes with Photothermal Effects for Enhanced Biofilm Eradication Against Periodontitis"],"prefix":"10.1002","volume":"13","author":[{"given":"Yinghui","family":"Wen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Research Unit of Oral Carcinogenesis and Management &amp; Chinese Academy of Medical Sciences West China Hospital of Stomatology Sichuan University  Chengdu Sichuan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Li","sequence":"additional","affiliation":[{"name":"School of Materials and Chemistry Southwest University of Science and Technology  Mianyang Sichuan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiannan","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Research Unit of Oral Carcinogenesis and Management &amp; Chinese Academy of Medical Sciences West China Hospital of Stomatology Sichuan University  Chengdu Sichuan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongkui","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Sichuan Provincial People's Hospital University of Electronic Science and Technology  Chengdu Sichuan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Research Unit of Oral Carcinogenesis and Management &amp; Chinese Academy of Medical Sciences West China Hospital of Stomatology Sichuan University  Chengdu Sichuan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Research Unit of Oral Carcinogenesis and Management &amp; Chinese Academy of Medical Sciences West China Hospital of Stomatology Sichuan University  Chengdu Sichuan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiping","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering College of Medicine Southwest Jiaotong University  Chengdu Sichuan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingxing","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Materials and Chemistry Southwest University of Science and Technology  Mianyang Sichuan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5336-7354","authenticated-orcid":false,"given":"Jiang","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Research Unit of Oral Carcinogenesis and Management &amp; Chinese Academy of Medical Sciences West China Hospital of Stomatology Sichuan University  Chengdu Sichuan P. R. 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