{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:44:25Z","timestamp":1791888265535,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Current clinical approaches for knee cartilage repair are often limited by hypertrophy and fibrosis in the regenerated tissues. A decellularized tissue\u2010engineered hyaline cartilage graft (dLhCG), composed of a type II collagen\u2010based extracellular matrix, has been developed to overcome this limitation. Extensive preclinical studies have demonstrated the ability of dLhCG to achieve hyaline cartilage repair and maintain a stable hyaline phenotype. In this prospective, first\u2010in\u2010human, exploratory clinical study (ChiCTR2400094194, ChiCTR2500100526, and ChiCTR2500105847), dLhCG was implanted to treat full\u2010thickness knee articular cartilage defects (Outerbridge grade III\/IV) in 17 patients. Stable graft integration with the surrounding native tissue was observed up to 18 months postoperatively. Significant improvements were noted in clinical outcome scores and MOCART scores. MRI T2 mapping evaluated as the ratio of repair\u2010tissue echo time to adjacent healthy cartilage, yielded values approaching 1, suggesting hyaline\u2010like biochemical and structural characteristics. No serious clinical adverse events were reported; asymptomatic imaging abnormalities, including bone marrow edema, were noted in some cases. These findings provide preliminary evidence of the feasibility, short\u2010term safety, and encouraging outcomes of dLhCG for hyaline\u2010like cartilage repair, warranting further investigation in controlled clinical trials.<\/jats:p>","DOI":"10.1002\/advs.202523106","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:45:08Z","timestamp":1791884708000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Clinical Study of Decellularized Tissue Engineering Hyaline Cartilage Graft (dLhCG) for Articular Cartilage Repair"],"prefix":"10.1002","author":[{"given":"Zhen","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering City University of Hong Kong  Kowloon Tong Hong Kong SAR People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Osteoarthropathy Yantaishan Hospital Yantaishan Hospital Affiliated to Binzhou Medical University Yantai  Yantai Shandong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyong","family":"Fei","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine Northern Jiangsu People's Hospital  Yangzhou Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuzhen","family":"Liang","sequence":"additional","affiliation":[{"name":"Sports Medicine Center Honghui Hospital Xi'an Jiaotong University  Xi'an Shanxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sports Medicine Center Honghui Hospital Xi'an Jiaotong University  Xi'an Shanxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kegui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Osteoarthropathy Yantaishan Hospital Yantaishan Hospital Affiliated to Binzhou Medical University Yantai  Yantai Shandong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihang","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine Northern Jiangsu People's Hospital  Yangzhou Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Cong","sequence":"additional","affiliation":[{"name":"Department of Osteoarthropathy Yantaishan Hospital Yantaishan Hospital Affiliated to Binzhou Medical University Yantai  Yantai Shandong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering City University of Hong Kong  Kowloon Tong Hong Kong SAR People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonglian","family":"Wu","sequence":"additional","affiliation":[{"name":"Center of Basic and Clinical Research in Sports Medicine Yangzhou University  Yangzhou Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Yantai Dinghao Biotechnology Co., Ltd.  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