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This study investigated the protective efficacy of\n                    <jats:italic>Lactiplantibacillus plantarum<\/jats:italic>\n                    GUANKE and the mechanisms associated with dendritic cell (DC)\u2010driven allergic airway inflammation (AAI). GUANKE conferred both prophylactic and therapeutic protection by attenuating airway hyperresponsiveness and Th2\u2010driven inflammation while partially restoring regulatory T cell (Treg) population. Antibiotic depletion and fecal microbiota transfer indicated that GUANKE\u2010mediated protection was associated with remodeling of the indigenous microbiota and microbiota\u2010dependent restoration of circulating indole\u20103\u2010acetic acid (IAA). Targeted serum metabolomics further revealed lower circulating IAA levels in patients with asthma than in healthy controls. Exogenous IAA reduced CX3CR1\n                    <jats:sup>+<\/jats:sup>\n                    Ly6C\n                    <jats:sup>\u2212<\/jats:sup>\n                    monocytic precursors and pulmonary CD11b\n                    <jats:sup>+<\/jats:sup>\n                    DC accumulation. These reductions were preserved after CD11c\u2010specific aryl hydrocarbon receptor (AhR) deletion and accompanied by reduced JAK3\u2010STAT3 signaling, lower STAT3 occupancy at the\n                    <jats:italic>Jag1<\/jats:italic>\n                    promoter, and attenuation of the Jag1\u2010Notch4\u2010Hey1 axis. Pharmacological STAT3 activation or Jagged1\u2010mediated Notch reactivation partially reversed the effects of IAA. Collectively, these findings link microbiota\u2010associated IAA restoration to GUANKE\u2010mediated protection and implicate STAT3\u2010Jag1\u2010Notch4 signaling in monocyte\u2010to\u2010DC differentiation during AAI.\n                  <\/jats:p>","DOI":"10.1002\/advs.202523466","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:29:31Z","timestamp":1789622971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte\u2010to\u2010DC Differentiation Via Microbiota\u2010Associated IAA"],"prefix":"10.1002","author":[{"given":"Yujia","family":"He","sequence":"first","affiliation":[{"name":"National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention &amp; Chinese Academy of Preventive Medicine  Beijing P. 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