{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:03:53Z","timestamp":1790370233267,"version":"4.1.0"},"reference-count":74,"publisher":"Wiley","issue":"29","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007270","name":"University of Michigan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tumor\u2010associated immunosuppressive neutrophils, termed polymorphonuclear myeloid\u2010derived suppressor cells (PMN\u2010MDSCs), compromise cancer immunotherapy. Emerging evidence indicates that neutrophil fate can be programmed as early as the hematopoietic stem and progenitor cell (HSPC) stage. Reprogramming HSPCs toward antitumor neutrophils offers a promising therapeutic strategy. Here, we demonstrate that an albumin\u2010bound STING agonist (Nano ZSA\u201051D) reprograms HSPCs to generate antitumor neutrophils, enhancing MHC I\u2010mediated CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell immunity and sensitizing tumors to \u03b1\u2010PD1 immunotherapy. Nano ZSA\u201051D expands HSPCs and reprograms them toward granulocyte\u2010monocyte progenitors for neutrophil development. It further converts immature (CD101\n                    <jats:sup>\u2212<\/jats:sup>\n                    ) and mature (CD101\n                    <jats:sup>+<\/jats:sup>\n                    ) neutrophils into a CD14\n                    <jats:sup>+<\/jats:sup>\n                    ICAM\u20101\n                    <jats:sup>+<\/jats:sup>\n                    subset through STING\u2010NF\u2010\u03baB\u2013TNF\u2010\u03b1 signaling, enhancing tumor infiltration and antitumor activity. These neutrophils upregulate interferon signaling and MHC I antigen presentation, thereby boosting tumor\u2010specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell responses. Notably, both adoptive transfer of Nano ZSA\u201051D\u2010reprogrammed neutrophils and systemic Nano ZSA\u201051D treatment synergizes with \u03b1\u2010PD1 therapy to achieve complete remission of colon tumors through neutrophil\u2010 and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell\u2010dependent mechanisms, with potent efficacy also validated in otherwise immune\u2010resistant pancreatic cancer models. Our findings establish a therapeutic strategy to reprogram HSPCs toward antitumor neutrophils, highlighting the potential of targeting early hematopoiesis to rewire neutrophil fate in cancer immunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/advs.202523603","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T13:40:01Z","timestamp":1773927601000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Albumin\u2010Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8\n                    <sup>+<\/sup>\n                    T Cell Immunity"],"prefix":"10.1002","volume":"13","author":[{"given":"Jinsong","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy Rogel Cancer Center University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Yi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy Rogel Cancer Center University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy Rogel Cancer Center University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanning","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy Rogel Cancer Center University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy Rogel Cancer Center University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuxia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy Rogel Cancer Center University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy Rogel Cancer Center University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy Rogel Cancer Center University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy Rogel Cancer Center University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering College of Engineering University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy Rogel Cancer Center University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Pharmacology and Pharmaceutical Sciences College of Pharmacy University of Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6406-2126","authenticated-orcid":false,"given":"Duxin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of 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