{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:56:16Z","timestamp":1790916976073,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"27","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22374112"],"award-info":[{"award-number":["22374112"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571215"],"award-info":[{"award-number":["82571215"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Efficient near\u2010infrared (NIR) photothermal conversion is constrained by photon loss from scattering and attenuation in complex media. We present a scattering\u2013absorption coupling strategy that pairs broadband photon scattering with plasmonic absorption to deliver supra\u2010additive heating. Nanodiamonds (ND) multiply scatter and trap NIR photons, elevating local photon density, while neighboring gold nanostars (AuNS) convert the enriched flux into heat with high efficiency. A multi\u2010scale framework links mechanism to outcome: finite\u2010difference time\u2010domain calculations quantify AuNS absorbed\u2010power gains in the proximity of ND, and Monte Carlo photon transport yields a depth\u2010dependent photon\u2010density enhancement that together predicts the measured temperature rises. In agarose phantoms and bacterial plates, ND increases NIR absorption and, when combined with AuNS, produces greater\u2010than\u2010additive heating. In cells, endogenous endocytosis brings ND and AuNS into lysosomal microenvironments that act as confined \u201chotspots\u201d enabling low\u2010power ablation; the power density required for 50% cell kill (LD\n                    <jats:sub>50<\/jats:sub>\n                    ) is reduced by a factor of 4.2 relative to AuNS alone. In in vivo experiments, AuNS and ND also exhibited a more potent photothermal therapeutic effect on mouse tumors. This principle provides a design rule for coupling scatterers and absorbers to overcome photon scarcity, offering a biocompatible route to efficient photothermal action with potential across oncology, anti\u2010infective therapy, and other light\u2010managed applications.\n                  <\/jats:p>","DOI":"10.1002\/advs.202523721","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T15:00:24Z","timestamp":1773068424000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Light\u2010Harvesting Photothermal Hotspots Enabled by NIR Scattering\u2010Absorption Coupling"],"prefix":"10.1002","volume":"13","author":[{"given":"Zebin","family":"Wu","sequence":"first","affiliation":[{"name":"The Institute for Advanced Studies (IAS) Department of Ophthalmology Zhongnan Hospital of Wuhan University State Key Laboratory of Metabolism and Regulation in Complex Organisms College of Life Sciences 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