{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:21:21Z","timestamp":1783113681906,"version":"3.54.6"},"reference-count":64,"publisher":"Wiley","issue":"34","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32471438"],"award-info":[{"award-number":["32471438"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32201143"],"award-info":[{"award-number":["32201143"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Activation of the STING pathway represents a potent strategy for cancer immunotherapy. However, the instability and systemic toxicity of STING agonists, especially cyclic dinucleotides (CDNs), limit their use via local administration with poor efficacy against metastatic or inaccessible tumors. Here, we develop an engineered silicasome nanocarrier for systemic delivery of the CDN ADU\u2010S100 (ADU\u2010Sili). Comprising ADU\u2010S100\u2010loaded mesoporous silica nanoparticles (MSNPs) coated with lipid bilayer, ADU\u2010Sili markedly enhanced tumor accumulation and antitumor efficacy compared with free ADU\u2010S100 and conventional liposomes in vivo. The advantage of systemic delivery was further demonstrated in bilateral tumors: ADU\u2010Sili induced systemic antitumor immunity, suppressing both tumors, whereas free ADU\u2010S100 inhibited only injected tumors. Immune profiling revealed that ADU\u2010Sili promoted dendritic cell maturation in lymph nodes, expanded cytotoxic and memory CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in spleens, elevated intratumoral effector cytokines, and polarized tumor\u2010associated macrophages toward an M1 phenotype. Notably, combining ADU\u2010Sili with immune checkpoint blockade (ICB) synergistically enhanced antitumor efficacy as demonstrated in more clinically relevant orthotopic tumor models. In summary, silicasomes enable effective systemic CDN delivery, eliciting robust immune and antitumor responses and overcoming intratumoral delivery limitations in STING\u2010based cancer immunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/advs.202523722","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T19:23:50Z","timestamp":1775762630000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nano\u2010Enabled Systemic Delivery of STING Agonist by Engineered Silicasome for Potent Antitumor Immunotherapy"],"prefix":"10.1002","volume":"13","author":[{"given":"Wenjing","family":"Zhou","sequence":"first","affiliation":[{"name":"School of Life Sciences Tianjin University Tianjin China"},{"name":"Zhejiang Cancer Hospital The Key Laboratory of Zhejiang Province for Basic and Clinical Application of Functional Nucleic Acids Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Li","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital The Key Laboratory of Zhejiang Province for Basic and Clinical Application of Functional Nucleic Acids Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Sun","sequence":"additional","affiliation":[{"name":"Fuyang Institute Zhejiang Chinese Medical University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghong","family":"Yang","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital The Key Laboratory of Zhejiang Province for Basic and Clinical Application of Functional Nucleic Acids Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences Hangzhou 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Chinese Academy of Sciences Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erli","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital The Key Laboratory of Zhejiang Province for Basic and Clinical Application of Functional Nucleic Acids Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital The Key Laboratory of Zhejiang Province for Basic and Clinical Application of Functional Nucleic Acids Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences Hangzhou China"},{"name":"College of Pharmaceutical Science Zhejiang University of Technology Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wei","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital The Key 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14352"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa8172"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910836"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar4060"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.101"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.01.004"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010018\u20100014\u2010x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010018\u20100007\u2010y"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12539"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.09.010"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3845"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2022.216038"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3581"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010022\u201004219\u2010z"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.04.025"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2022.06.010"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.10.017"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010020\u201001250\u20101"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010020\u201000916\u2010z"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326\u20106066.CIR\u201014\u20100099"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.11.047"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abn6612"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.04.031"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.3c00394"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1661"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262\u2010023\u201003502\u20107"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.03.054"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adj9366"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.202000130"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c14273"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.02.029"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b07781"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b06164"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2018.1433981"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol101236b"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b00510"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018\u2010022\u201000468\u2010w"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.015283"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15640"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja902039y"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn204102q"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010017\u201000573\u2010w"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010021\u201000962\u20109"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102021\u2010002852"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa4306"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201080999\u2010x"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102021\u2010002474"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.21037\/tp\u201021\u2010372"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15225415"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201047308\u2010z"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010021\u201001166\u20103"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201022\u20102235"},{"key":"e_1_2_10_54_1","doi-asserted-by":"pub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