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The mechanism behind this phenomenon remains largely unknown. Here, we found that offspring from colitic dams exhibit increased brain weight. These offspring also show excessive neural stem cell (NSC) proliferation and behavioral deficits. Furthermore, Gsdmd cleavage is elevated in the colonic epithelium of colitic dams. This increase is associated with developmental abnormalities in the fetal brain. Mechanistically, excessive NSC proliferation is driven by increased IL\u201033 release from the maternal colonic epithelium in a Gsdmd\u2010dependent manner. In contrast, we found no evidence that maternal luminal LPS leakage or increased fetal microglia accounts for this phenotype. 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