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Accurate and systematic comparison of toxicity responses among different materials is essential for developing environmentally friendly and safer advanced technologies. In this study, we report a unique phenomenon in toxicity comparison: the relative toxicity ranking between two perovskite compositions reverses when the animal species is changed. We quantitatively assess and compare toxicity responses ranging from macroscopic observations (body weight, organ index, and blood biochemistry) to molecular\u2010level responses (transcriptomic alterations) across different species and material compositions. Our results reveal that the toxicity variation induced by a species change (from mice to rabbits) exceeds that caused by a compositional change (from lead to tin perovskite). The tiny overlap of damaged genes and biological pathways between mice and rabbits accounts for the pronounced interspecies toxicity differences. Furthermore, tin\u2010based perovskites display greater sensitivity to species variation than their lead\u2010based counterparts. Consequently, while lead\u2010based perovskites are more toxic in mice, this trend reverses in rabbits, where tin\u2010based perovskites exhibit higher toxicity. This work provides new insight into how species\u2010dependent biomolecular responses fundamentally shape toxicity comparison outcomes.<\/jats:p>","DOI":"10.1002\/advs.202523889","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T19:38:33Z","timestamp":1774985913000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Species Dependent Toxicity Comparison Outcome"],"prefix":"10.1002","volume":"13","author":[{"given":"Lian","family":"Xiao","sequence":"first","affiliation":[{"name":"School of Physics East China University of Science and Technology  Shanghai China"},{"name":"Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan","family":"Yu","sequence":"additional","affiliation":[{"name":"Beijing An Zhen Hospital Affiliated of Capital University of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihang","family":"Liu","sequence":"additional","affiliation":[{"name":"Research Institute of Aero\u2010Engine Beihang University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Research Institute of Aero\u2010Engine Beihang University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Deng","sequence":"additional","affiliation":[{"name":"Research Institute of Aero\u2010Engine Beihang University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yugang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Multiphase Flow and Heat Transfer in Power Engineering, School of Energy and Power Engineering University of Shanghai for Science and Technology Shanghai 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