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Endovascular stenting remains a primary therapeutic approach; however, the development of biodegradable vascular stents that offer both sufficient mechanical resilience and antithrombotic, anti\u2010restenotic surfaces remains challenging, especially in highly deformable peripheral vessels. Herein, a 3D\u2010printed biodegradable drug\u2010eluting stent (DES) based on biofunctional silica\u2013polycaprolactone nanocomposites and Janus surface nanoengineering is presented. Sol\u2013gel\u2010derived silica incorporation and extrusion\u2010based 3D printing yield stents with tuned radial strength, elliptical struts that reduce flow disturbance, and enhanced support for endothelial regeneration. Janus nanoengineering is achieved through tantalum (Ta) plasma immersion ion implantation. The resultant nano\u2010Ta\u2010enriched luminal surface promotes human umbilical vein endothelial cell adhesion and proliferation. Meanwhile, the abluminal layer, comprising sirolimus\/poly\u2010\n                    <jats:italic>L<\/jats:italic>\n                    \u2010lactic acid and nano\u2010Ta, suppresses vascular smooth muscle cell proliferation, reduces platelet thrombosis, and minimizes the initial burst release of therapeutic agents. Comprehensive in vitro hemocompatibility and cytocompatibility studies, combined with in vivo evaluation in a PAD model, demonstrate improved patency, reduced neointimal hyperplasia, and favorable tissue responses. This 3D\u2010printed, Janus\u2010engineered DES represents a promising theragenerative platform for vascular tissue engineering.\n                  <\/jats:p>","DOI":"10.1002\/advs.202523965","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T19:27:33Z","timestamp":1774985253000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mechanically Robust Biodegradable Stents With Theragenerative Vascular Responses via Combined 3D Printing and Janus Nanoengineering"],"prefix":"10.1002","volume":"13","author":[{"given":"Jong Hwa","family":"Seo","sequence":"first","affiliation":[{"name":"Division of Materials Science and Engineering Hanyang University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Sung","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Convergence Medicine Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"},{"name":"Biomedical Engineering Research Center Asan Institute for Life Sciences Asan Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Research Institute of Intelligent Manufacturing &amp; 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