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Accumulated ferrous ions (Fe\n                    <jats:sup>2+<\/jats:sup>\n                    ) and increased intracellular viscosity promote of ferroptosis. Precisely monitoring Fe\n                    <jats:sup>2+<\/jats:sup>\n                    \/Viscosity, especially in ferroptosis, is crucial for PD theranostic. However, a feasible strategy is lacking. In this study, series of Fe\n                    <jats:sup>2+<\/jats:sup>\n                    \/Viscosity cascade\u2010activated near\u2010infrared fluorescence probes (NP1\u20135) are synthesized. Through optical characterization and theoretical calculations, NP3 is selected as the optimal probe to monitor Fe\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    \/Viscosity via redox reactions and twisted intramolecular charge transfer processes. To verify this concept in the context of ferroptosis intervention in PD, an innovative nanoplatform is constructed based on NP3 and quercetin, modified with rabies virus glycoprotein\u201029 and defined as PQR nanoparticles (PQR NPs). In vitro and in vivo experiments demonstrate that PQR NPs not only alleviate ferroptosis\u2010induced loss of dopaminergic neurons by reducing oxidative stress and neuroinflammation, mitigating \u03b1\u2010synuclein aggregation, and restoring mitochondrial function, but also could monitor the elevated Fe\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    \/Viscosity in ferroptosis of PD models. Present study developed a facile tool for monitoring Fe\n                    <jats:sup>2+<\/jats:sup>\n                    \/Viscosity in ferroptosis. The findings have strong application potential in theranostics of PD and other ferroptosis related diseases.\n                  <\/jats:p>","DOI":"10.1002\/advs.202524057","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:34:24Z","timestamp":1773009264000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Molecularly Engineered Phenoxazinone\u2010Skeleton Cascade\u2010Activated NIR Probes for Monitoring Fe\n                    <sup>2+<\/sup>\n                    \/Viscosity in Ferroptosis\u2010Mediated Parkinson's Disease"],"prefix":"10.1002","volume":"13","author":[{"given":"Lixia","family":"Guo","sequence":"first","affiliation":[{"name":"Third Hospital of Shanxi Medical University Shanxi Bethune Hospital  Taiyuan P. R. China"},{"name":"School of Basic Medical Sciences Shanxi Medical University  Taiyuan P. R. 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