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To enhance the oral bioavailability of polyphenols, we architected a colon\u2013targeted W\n                    <jats:sub>1<\/jats:sub>\n                    \/O\/W\n                    <jats:sub>2<\/jats:sub>\n                    emulsion system featuring a rationally designed lignin\u2013carbohydrate complex (LCC) as a dual\u2013functional emulsifier system for the first time. Based on the innate structural duality of LCC, which comprising hydrophobic lignin and hydrophilic carbohydrates, we employed LCC for O\/W emulsifier. This inherent amphiphilicity was further engineered via laccase\u2013mediated grafting of isovanillin, yielding a modified LCC with tailored lipophilicity for effective W\/O interfacial stabilization. The W\n                    <jats:sub>1<\/jats:sub>\n                    \/O\/W\n                    <jats:sub>2<\/jats:sub>\n                    emulsion ensured the stability of the encapsulated polyphenols with divergent polarity but also enabled pH\u2013responsive payload release under colonic conditions (pH &gt;7.0). In DSS\u2013induced colitis, the system demonstrated a synergistic effect, the LCC itself acted as a prebiotic to modulate the gut microbiota, specifically enriching short chain fatty acid\u2013producing bacteria, while the released polyphenols reinforced the intestinal barrier, which collectively accelerated mucosal healing. This research proposes a carbon\u2013neutral therapeutic strategy for colitis, not only establishing a proof\u2013of\u2013concept for replacing synthetic emulsifiers with engineered biomass, but also as a multi\u2013functional platform to stabilize colon\u2013targeted co\u2013delivery system and microbiome regulation in colitis.\n                  <\/jats:p>","DOI":"10.1002\/advs.202524070","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T10:40:21Z","timestamp":1773312021000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Constraint of Lignin\u2013Carbohydrate Complex Orchestrated on Polyphenol in Oil\u2013Water Interface Targeting Ulcerative Colitis Therapy"],"prefix":"10.1002","volume":"13","author":[{"given":"Qian","family":"Wu","sequence":"first","affiliation":[{"name":"National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics Hubei University of 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