{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:03:37Z","timestamp":1790949817691,"version":"4.1.0"},"reference-count":218,"publisher":"Wiley","issue":"36","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["101002060"],"award-info":[{"award-number":["101002060"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Oxygen delivery and reactive oxygen species regulation are tightly linked in physiology, with red blood cells serving both as oxygen transporters and as a key antioxidant barrier. This dual function has motivated decades of research into hemoglobin (Hb)\u2010based oxygen carriers (HBOCs), yet conventional designs remain susceptible to oxidative damage and lack the redox machinery of erythrocytes. In parallel, nanozymes\u2014nanomaterials with enzyme\u2010mimetic catalytic activities\u2014have emerged as powerful tools in redox medicine. Their integration with HBOCs has created a new class of self\u2010protecting, multifunctional, and stimuli\u2010responsive oxygen therapeutics. This review summarizes the foundations and biomedical potential of nanozyme\u2010integrated HBOCs and Hb\u2010derived nanozymes. We outline how metal, carbon, and metal\u2013organic framework nanozymes replicate key antioxidant functions, including superoxide dismutase\u2010, catalase\u2010, and peroxidase\u2010like activity. Embedding such nanozymes into HBOCs imparts intrinsic oxidative protection and additional capabilities such as carbonic anhydrase\u2010like catalysis, transforming passive oxygen carriers into intelligent blood substitutes. We then highlight applications beyond transfusion, including wound healing, where photothermal nanozyme\u2013HBOC hybrids enable light\u2010controlled oxygen release and antibacterial action, and cancer therapy, where catalytic HBOCs alleviate tumor hypoxia and enhance radiotherapy, photothermal therapy, and photodynamic therapy. Finally, we discuss Hb\u2010derived and erythrocyte\u2010templated nanozymes for biosensing, radioprotection, and infection control.<\/jats:p>","DOI":"10.1002\/advs.202524094","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T12:56:48Z","timestamp":1779281808000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nanozymes for Advanced Hemoglobin\u2010Based Oxygen Carriers: Applications in Blood Substitution, Wound Healing, Antitumor Therapy, and Beyond"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0167-5990","authenticated-orcid":false,"given":"Despoina","family":"Douka","sequence":"first","affiliation":[{"name":"Department of Health Technology Technical University of Denmark  Kongens Lyngby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9852-3841","authenticated-orcid":false,"given":"Ana Mar\u00eda","family":"Pablo\u2010Sainz\u2010Ezquerra","sequence":"additional","affiliation":[{"name":"Department of Health Technology Technical University of Denmark  Kongens Lyngby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3657-1254","authenticated-orcid":false,"given":"Eva","family":"Jakljevi\u010d","sequence":"additional","affiliation":[{"name":"Department of Health Technology Technical University of Denmark  Kongens Lyngby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8308-3646","authenticated-orcid":false,"given":"Niki","family":"Ktena","sequence":"additional","affiliation":[{"name":"Department of Health Technology Technical University of Denmark  Kongens Lyngby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8177-4806","authenticated-orcid":false,"given":"Leticia","family":"Hosta\u2010Rigau","sequence":"additional","affiliation":[{"name":"Department of Health Technology Technical University of Denmark  Kongens Lyngby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2012.13659"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2008.12.006"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-40717-8_1"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1464"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002907\u20105"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202211041"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201062063\u20108"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c14822"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2bm01405j"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110541"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3ra00689a"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201901254"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201040474\u20109"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c06541"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2022.103824"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.4c06311"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/bios13060583"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202307844"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.124.3220.467"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014\u20105793(76)80847\u20102"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr9403704"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr980039a"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00410a040"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.9.4262"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3787261"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200460649"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200703371"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc700184b"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2007.260"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00140"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2018.05.012"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c07520"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201803804"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2020.08.020"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn300291r"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010021\u201001182\u2010y"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3an01906c"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.1cC00574"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200800023"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b12212"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b03525"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/cm100393v"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/c6nr05015h"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200903783"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2014.03.023"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274\u2010011\u20100147\u20104"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2011.11.003"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.8b02726"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5bb08945"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201801010"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1039\/c6ra02911f"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201705989"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2014.08.026"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3dt02822d"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micromeso.2022.111773"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aav5490"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274\u2010022\u20104856\u20107"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2022.101493"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202116170"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8cs00457a"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201800384"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0bm01767a"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2018.08.006"},{"key":"e_1_2_12_65_1","first-page":"197","volume-title":"Damage Control Resuscitation: Identification and Treatment of Life\u2010Threatening Hemorrhage","author":"Gupta S.","year":"2019"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202315879"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2025.216508"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.09.002"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0798\u2010667"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja050339r"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm5004256"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9nr06596b"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm400204y"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149526"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep12778"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1039\/tf9565201235"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2005.07.075"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/asia.201301285"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1997.0341"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304\u20105102(81)85025\u20100"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0nr00875c"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201036303\u20108"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b19865"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200902672"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2024.102163"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-64081-9.00005-X"},{"issue":"1","key":"e_1_2_12_87_1","first-page":"37","article-title":"Repeated Injections of PEG\u2010PE Liposomes Generate Anti\u2010PEG Antibodies","volume":"10","author":"\u015aroda K.","year":"2005","journal-title":"Cellular & Molecular Biology Letters"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1106634108"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201502388"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.14471"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym12020298"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.201900170"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5473.2051"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201200138"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14874"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.02.041"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2022.112691"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1039\/c7cc09173g"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2015.18"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201704303"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/viw2.20"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201606134"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201906846"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0bm01118e"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1bm01005k"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346\u2010022\u201001232\u20104"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2018.02.088"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40820\u2010020\u201000532\u2010z"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja806804u"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12551\u2010012\u20100076\u20109"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1097\/ccm.0b013e318206b1fa"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.3109\/10731199.2013.745291"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2009.10.021"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102406"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c01059"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.3C00352"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2012.05.001"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100687"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1097\/gox.0000000000003136"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2010.09804.x"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021012070"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b10096"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8cs00561c"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201500208"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201502615"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201007835\u20101"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/am.2017.225"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1039\/c5cs00811e"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b05825"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1039\/c5nr02324f"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2018.08.008"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b03483"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201706664"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42242\u2010018\u20100028\u20108"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40843\u2010016\u20105151\u20106"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/B0-12-370879-6\/00288-X"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.3c00488"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmaterialslett.3C00287"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c18809"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.2c01895"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.2c01333"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9nr04348a"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12967"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202102113"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1714421115"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213\u20108587(20)30343\u20100"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2012.10.001"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122029"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120623"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42765\u2010022\u201000180\u20105"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201024697\u20102"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202000035"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2015.02.003"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.126525"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppsc.202000169"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2016268117"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2015.11.014"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2021.110219"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0b013e3182251559"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.110785"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2021.649158"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.70700"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.s140462"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2023.100775"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010024\u201005845\u2010w"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.4c00258"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.666017"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2C15015"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.2c00475"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c02528"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c09505"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c01591"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1002\/anbr.202500082"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smaim.2025.04.001"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1568169"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2025.114573"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.704"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2025.1604616"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1002\/mba2.70010"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202103497"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201504617"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.108"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1411499111"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2018.06.005"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201003705\u2010y"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn300149c"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcornel.2013.09.013"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.15171\/apb.2017.041"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12626"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncl\/djm135"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1893"},{"key":"e_1_2_12_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2015.12.017"},{"key":"e_1_2_12_193_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555\u2010012\u20109415\u20103"},{"key":"e_1_2_12_194_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27681"},{"key":"e_1_2_12_195_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar200017e"},{"key":"e_1_2_12_196_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890\u2010200212270\u201000030"},{"key":"e_1_2_12_197_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201301655"},{"key":"e_1_2_12_198_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202503206"},{"key":"e_1_2_12_199_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c03831"},{"key":"e_1_2_12_200_1","doi-asserted-by":"publisher","DOI":"10.1002\/ente.202000667"},{"key":"e_1_2_12_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2020.03.010"},{"key":"e_1_2_12_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2020.111200"},{"key":"e_1_2_12_203_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c01780"},{"key":"e_1_2_12_204_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.s207666"},{"key":"e_1_2_12_205_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.1c00005"},{"key":"e_1_2_12_206_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1tb02646a"},{"key":"e_1_2_12_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2023.115425"},{"key":"e_1_2_12_208_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.3c04652"},{"key":"e_1_2_12_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canler.2019.03.020"},{"key":"e_1_2_12_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2018.02.008"},{"key":"e_1_2_12_211_1","doi-asserted-by":"publisher","DOI":"10.1039\/c7cs00891k"},{"key":"e_1_2_12_212_1","doi-asserted-by":"publisher","DOI":"10.1039\/c5ra23081k"},{"key":"e_1_2_12_213_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi0483211"},{"key":"e_1_2_12_214_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja003687w"},{"key":"e_1_2_12_215_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010030\u201041769\u20107_14"},{"key":"e_1_2_12_216_1","doi-asserted-by":"publisher","DOI":"10.9790\/5736\u2010071123846"},{"key":"e_1_2_12_217_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3bm00884c"},{"key":"e_1_2_12_218_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202512409"},{"key":"e_1_2_12_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.142798"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202524094","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202524094","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202524094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T08:03:38Z","timestamp":1783843418000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202524094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,20]]},"references-count":218,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/advs.202524094"],"URL":"https:\/\/doi.org\/10.1002\/advs.202524094","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,20]]},"assertion":[{"value":"2025-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e24094"}}