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The dorsal root ganglion (DRG) neurons constitute the hubs of this system. Moreover, beyond their canonical role within the interoceptive pathway, these neurons exert a direct effector role by secreting calcitonin gene\u2010related peptide (CGRP) to promote bone repair. However, current sensory nerve\u2010targeted strategies in bone tissue engineering remain static, bypassing the dynamic reflex arc and failing to establish an autonomous functional system. To address this, a streamlined interoception unit was engineered using neural bioprinting of DRG neurons within piezoelectric scaffolds. Upon sensing ultrasound (US) stimulation, the piezoelectric poly(l\u2010lactide) (PLLA) component mediates mechanoelectrical coupling, triggering a Ca\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    influx\u2010induced effector response in the incorporated DRG neurons that enhances CGRP secretion and expression. The secreted CGRP subsequently promotes osteogenesis and angiogenesis in vitro and accelerates neuro\u2010vascularized bone regeneration in a rat femoral condyle defect model. This study established a bioinspired platform with a self\u2010contained \u201csensor\u2010effector\u201d circuit, offering a novel engineered strategy for bone regeneration.\n                  <\/jats:p>","DOI":"10.1002\/advs.202524181","type":"journal-article","created":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T11:02:52Z","timestamp":1771153372000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Bioinspired Engineering of Streamlined Skeletal Interoception: Neural Bioprinted Piezoelectric Scaffolds for Neuro\u2010Vascularized Bone Regeneration"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8538-1873","authenticated-orcid":false,"given":"Yingze","family":"Su","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai People's Republic of 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