{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:28:11Z","timestamp":1787596091911,"version":"build-2736575974"},"reference-count":67,"publisher":"Wiley","issue":"47","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC 2033 \u2013 390677874"],"award-info":[{"award-number":["EXC 2033 \u2013 390677874"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Neutrophils are key inflammatory effector cells and rapidly integrate chemical signals during inflammation. They have long been suspected to use catecholamines (CAs) as immunoregulatory signals, but direct evidence for CA handling in these cells has been lacking due to the absence of suitable real\u2010time detection tools. Here, we combine fluorescent false neurotransmitters (FFNs), near\u2010infrared fluorescent single\u2010walled carbon nanotube (SWCNT)\u2010based catecholamine nanosensors, dual\u2010color Ca\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    imaging, and transcriptomics to resolve neutrophil CA dynamics with high spatiotemporal precision. Using FFNs, we demonstrate VMAT2\u2010dependent vesicular uptake of catecholamines within seconds as well as CA transfer between cells. Serotonin, LPS, and activated platelets trigger calcium (Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ) signaling and subsequent fast transient release of CAs from neutrophils, which we directly visualize in real time using SWCNT\u2010based nanosensors. In human experimental endotoxemia, longitudinal transcriptomics reveal coordinated regulation of monoaminergic receptors, synthesis machinery, and transporters, suggesting adaptive tuning of neutrophils to inflammatory CA exposure. CAs suppress NET formation but enhance thrombin\u2010induced platelet aggregation, and serotonin\u2010dependent platelet\u2013neutrophil interactions evoke CA release, establishing a paracrine feedback loop linking inflammation and coagulation. Our integrated imaging and sensing workflow provides direct evidence for rapid vesicular catecholamine communication in human neutrophils and uncovers previously unrecognized mechanistic parallels between neurons and neutrophils. It offers a broadly applicable platform to interrogate monoamine signaling in immune cells.\n                  <\/jats:p>","DOI":"10.1002\/advs.202524193","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T19:18:14Z","timestamp":1781810294000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6500-5298","authenticated-orcid":false,"given":"Jennifer","family":"Mohr","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry Ruhr University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital M\u00fcnster  M\u00fcnster 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Georg\u2010August\u2010University  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Daniel","sequence":"additional","affiliation":[{"name":"Department of Molecular Neurobiology Max Planck Institute For Multidisciplinary Sciences  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Jung","sequence":"additional","affiliation":[{"name":"ZEMOS Center for Solvation Science Ruhr University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Eble","sequence":"additional","affiliation":[{"name":"Institute of Physiological Chemistry and Pathobiochemistry University of M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Wabnitz","sequence":"additional","affiliation":[{"name":"Institute For Immunology Heidelberg University Hospital Heidelberg  Heidelberg 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