{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:09:06Z","timestamp":1789142946945,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"32","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102903"],"award-info":[{"award-number":["82102903"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LR25C100002"],"award-info":[{"award-number":["LR25C100002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Recurrence and metastasis are the primary causes of mortality in hepatocellular carcinoma (HCC), primarily driven by an immunosuppressive tumor microenvironment. This study developed a multifunctional flexible patch (MnO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010P\u2010ICG NFs) based on electrospun SiO\n                    <jats:sub>2<\/jats:sub>\n                    gel fibers whose surface is modified with a layer of \u201cnest\u2010like\u201d MnO\n                    <jats:sub>2<\/jats:sub>\n                    . The patch enables the co\u2010delivery of indocyanine green (ICG) and pachymaran directly to the tumor site via a laparoscopic system. Under near\u2010infrared light irradiation, ICG serves as a photosensitizer for photodynamic therapy (PDT), effectively ablating tumors and inducing immunogenic cell death (ICD), thereby activating antitumor immunity. Meanwhile, pachymaran, with its immunomodulatory effects, preferential activates natural killer (NK) cells to exert antitumor effects. Additionally, PDT further enhances this immune response by activating the cGAS\u2010STING pathway. In mouse models, implantation of the patch significantly inhibited primary liver tumor progression and ascites formation. In a malignant liver tumor model, MnO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010P\u2010ICG NFs prevented local recurrence in 80% of treated mice. Notably, both the depletion of NK cells and the blockade of the cGAS\u2010STING pathway compromised the therapeutic efficacy of MnO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010P\u2010ICG NFs. Clinically, tumors with higher NK cell infiltration were associated with improved patient outcomes. In conclusion, this versatile patch provides a promising therapeutic strategy for patients with advanced HCC.\n                  <\/jats:p>","DOI":"10.1002\/advs.202524246","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:54:32Z","timestamp":1775282072000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Laparoscopic Delivery of a MnO\n                    <sub>2<\/sub>\n                    \u2010P\u2010ICG Patch for Photodynamic Therapy and NK Cell\u2010Driven Immunotherapy in Hepatocellular Carcinoma"],"prefix":"10.1002","volume":"13","author":[{"given":"Jie","family":"Lin","sequence":"first","affiliation":[{"name":"Department of General Surgery Sir Run\u2010Run Shaw Hospital Zhejiang University  Hangzhou China"},{"name":"National Engineering Research Center of Innovation and Application of Minimally Invasive Instruments Sir Run\u2010Run Shaw Hospital Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoqi","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of General Surgery Sir Run\u2010Run Shaw Hospital Zhejiang University  Hangzhou China"},{"name":"Department of Pancreatic Surgery Fudan University Shanghai Cancer Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Sir Run\u2010Run Shaw Hospital Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Nan","sequence":"additional","affiliation":[{"name":"Department of General Surgery Sir Run\u2010Run Shaw Hospital Zhejiang University  Hangzhou China"},{"name":"National Engineering Research Center of Innovation and Application of Minimally Invasive Instruments Sir Run\u2010Run Shaw Hospital Zhejiang University  Hangzhou 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Run\u2010Run Shaw Hospital Zhejiang University  Hangzhou China"},{"name":"National Engineering Research Center of Innovation and Application of Minimally Invasive Instruments Sir Run\u2010Run Shaw Hospital Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boqiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Sir Run\u2010Run Shaw Hospital Zhejiang University  Hangzhou China"},{"name":"National Engineering Research Center of Innovation and Application of Minimally Invasive Instruments Sir Run\u2010Run Shaw Hospital Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Wu","sequence":"additional","affiliation":[{"name":"Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical University  Fuzhou 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