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Here, a novel cold\u2010lamination strategy is developed to mechanically interlock a TPU nanomesh within a temperature\u2010responsive hydrogel network, mimicking the structure of the extracellular matrix. This method enables the fabrication of devices with precise control of thickness (17\u201390 \u00b5m), tunable Young's modulus (36.5\u2013761.1\u00a0kPa), excellent breathability, and large\u2010area scalability (&gt;\u00a0225 cm\n                    <jats:sup>2<\/jats:sup>\n                    ). Furthermore, the resulting bioelectronics exhibit reversible, on\u2010demand adhesion enabled by switchable hydrogen\u2010bond interactions. The ultrathin hydrogels exhibit exceptional conformability and durability, with a 17 \u00b5m film achieving tensile stress of 835.23\u00a0kPa and toughness of 1.57\u00a0MJ m\n                    <jats:sup>\u22123<\/jats:sup>\n                    , thereby overcoming the fragility of conventional ultrathin films. By forming stable tissue interfaces, they enabled reliable epidermal electrocardiogram monitoring under daily and clinical conditions and served as implantable cardiac patches for arrhythmia detection in mice. When integrated with a dual\u2010branch deep learning network, the intelligent platform achieved 99% in vivo classification accuracy of ventricular tachycardia, ventricular fibrillation, and other arrhythmias. Together, these results establish a broadly adaptable hydrogel system, offering a universal and scalable strategy for next\u2010generation bioelectronics tailored to diverse organ\u2010specific demands.\n                  <\/jats:p>","DOI":"10.1002\/advs.202524317","type":"journal-article","created":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T12:02:53Z","timestamp":1771156973000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Bioinspired Cold\u2010Laminated Ultrathin Hydrogels as a Broadly Adaptive Platform for Physiological Monitoring"],"prefix":"10.1002","volume":"13","author":[{"given":"Hui","family":"Chen","sequence":"first","affiliation":[{"name":"College of Mechanical and Vehicle Engineering Hunan University  Changsha 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