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Here, a clinically relevant strategy is reported that converts a dura mater into an active piezoelectric patch to noninvasively drive endogenous NSC neurogenesis. Electrospun poly(L\u2011lactic acid) (PLLA) patches were subjected to surface confinement crystallization on metal substrates, producing a metastable \u03b1\u2032 crystal structure and markedly enhanced piezoelectric output. Under low\u2011intensity transcranial ultrasound, the treated patch generates reproducible pulsed electrical signals that remodel the local injury microenvironment. In vitro and in vivo assays show that ultrasound\u2011activated patches increase neuronal lineage differentiation (neurons\/astrocytes ratio increased \u223c9.6\u2011fold at 14 days) and promote greater neuronal maturation, while concomitantly modulating the immune milieu. In a rat TBI model, daily 2\u2011min ultrasound stimulation delivered via the patch substantially accelerated tissue repair and improved behavioral and cognitive outcomes compared with untreated controls. This work demonstrates a simple, scalable modification of clinical artificial dura mater to produce a soft, biodegradable piezoelectric implant capable of remote, noninvasive electrical modulation of endogenous NSCs, with broad implications for neural regeneration and potential clinical translation.<\/jats:p>","DOI":"10.1002\/advs.202524326","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:32:09Z","timestamp":1772998329000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ultrasound Activated Piezoelectric Dural Patches to Drive Endogenous Neural Stem Cell\u2013Mediated Repair Traumatic Brain Injury"],"prefix":"10.1002","volume":"13","author":[{"given":"Pengbo","family":"Zhou","sequence":"first","affiliation":[{"name":"The First School of Clinical Medical Lanzhou University  Lanzhou Gansu China"},{"name":"Centre for Neurological Diseases Research Characteristic Medical Center of People's Armed Police Forces  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Chemistry Key Laboratory of Bioorganic Phosphorus Chemistry &amp; Chemical Biology Tsinghua University  Beijing China"},{"name":"Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic\u2010Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials &amp; Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing University of Chemical Technology  Beijing P. 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