{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T14:54:29Z","timestamp":1781535269640,"version":"3.54.5"},"reference-count":127,"publisher":"Wiley","issue":"30","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020415","name":"Additional Ventures","doi-asserted-by":"publisher","award":["Expansion Award"],"award-info":[{"award-number":["Expansion Award"]}],"id":[{"id":"10.13039\/100020415","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH126195"],"award-info":[{"award-number":["R01 MH126195"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CAREER 2044657"],"award-info":[{"award-number":["CAREER 2044657"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL131017\u201005"],"award-info":[{"award-number":["R01 HL131017\u201005"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Fontan\u2010associated liver disease (FALD) is a progressive complication of Fontan circulation, driven by chronically elevated central venous pressure (CVP) and hypoxia. Current experimental models lack the fidelity to fully recapitulate the complex hemodynamic and cellular microenvironment of the liver sinusoid under Fontan physiology, limiting mechanistic insights and therapeutic discovery. We developed a perfusable, 3D bioengineered human liver sinusoid model incorporating hepatocytes and endothelial cells within a multilayered construct. The platform was cultured under tunable flow and oxygen, simulating physiological and pathological CVP. Structural and mechanical fidelity were assessed using electron microscopy and microindentation. Hemodynamic measurements by catheter and particle image velocimetry were in agreement with those predicted by computational modeling. Sinusoid analogues maintained their architecture, endothelial coverage, and hepatic viability and function over 21 days of culture. Elevated pressure and hypoxia resulted in endothelial activation (VCAM\u20101, ET\u20101), hepatocellular stress (HIF1\u03b1), fibronectin\u2010rich tissue remodeling, and altered hepatic function (albumin, bile acid, LDH, TGF\u2010\u03b2), consistent with early FALD pathology. Structural and molecular responses were altered with varying pressure and oxygen, confirming the platform's sensitivity to mechanical and metabolic cues. This bioengineered 3D model successfully reproduced the key early features of FALD pathophysiology, enabling controlled interrogation of pressure\u2010 and hypoxia\u2010induced liver injury.<\/jats:p>","DOI":"10.1002\/advs.202524337","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T15:41:12Z","timestamp":1775662872000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Dynamic 3D Human Liver Sinusoid Model for Mechanistic Interrogation of Fontan\u2010Associated Liver Disease"],"prefix":"10.1002","volume":"13","author":[{"given":"Sarah","family":"Rezapourdamanab","sequence":"first","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering Emory University School of Medicine and Georgia Institute of Technology  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi Salar","family":"Amoli","sequence":"additional","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering Emory University School of Medicine and Georgia Institute of Technology  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanmay","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Bagheri","sequence":"additional","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering Emory University School of Medicine and Georgia Institute of Technology  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boeun","family":"Hwang","sequence":"additional","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering Emory University School of Medicine and Georgia Institute of Technology  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linqi","family":"Jin","sequence":"additional","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering Emory University School of Medicine and Georgia Institute of Technology  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamini","family":"Singh","sequence":"additional","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering Emory University School of Medicine and Georgia Institute of Technology  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Norton","sequence":"additional","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering Emory University School of Medicine and Georgia Institute of Technology  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashay Vishwas","family":"Bongirwar","sequence":"additional","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering Emory University School of Medicine and Georgia Institute of Technology  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Karnik","sequence":"additional","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering Emory University School of Medicine and Georgia Institute of Technology  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi Prasad","family":"Dasi","sequence":"additional","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering Emory University School of Medicine and Georgia Institute of Technology  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Avazmohammadi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Texas A&amp;M University  College Station Texas USA"},{"name":"Department of Mechanical Engineering Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"Romero","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology Hepatology and Nutrition Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Children's Healthcare of Atlanta  Atlanta Georgia USA"},{"name":"Department of Pediatrics Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly D.","family":"Bauser\u2010Heaton","sequence":"additional","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering Emory University School of Medicine and Georgia Institute of Technology  Atlanta Georgia USA"},{"name":"Children's Healthcare of Atlanta  Atlanta Georgia USA"},{"name":"Department of Pediatrics Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Sibley Heart Center At Children's Healthcare of Atlanta  Atlanta Georgia USA"},{"name":"Children's Heart Institute McGovern Medical School UTHealth  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5304-095X","authenticated-orcid":false,"given":"Vahid","family":"Serpooshan","sequence":"additional","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering Emory University School of Medicine and Georgia Institute of Technology  Atlanta Georgia USA"},{"name":"Children's Healthcare of Atlanta  Atlanta Georgia USA"},{"name":"Department of Pediatrics Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Children's Heart Institute McGovern Medical School UTHealth  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247\u2010020\u201004776\u20100"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.109.875021"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.036821"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12570"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.312105027"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.045597"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1100514"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2022.04.014"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.117.004515"},{"issue":"5","key":"e_1_2_9_11_1","article-title":"The Pathophysiology and Complications of Fontan Circulation","volume":"92","author":"Mazza G. A.","year":"2021","journal-title":"Acta Biomed"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/CLD.0000000000000061"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.15420\/usc.2022.02"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32406"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.03.013"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010016\u20104614\u2010x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7125193"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd8030030"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0271223"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202170071"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.14366\/usg.14029"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i11.1355"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/HC9.0000000000000318"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adi0759"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100030\u20101250124"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.11.031"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00380\u2010019\u201001544\u20105"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13092601"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01707667"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivz022"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e31823c0aa4"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjon.2024.06.018"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adk6213"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1829148"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau7307"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1567916"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010018\u20100097\u20103"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13081217"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13050727"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2025.103725"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsapm.3c01309"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb15030077"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1557\/jmr.2004.19.1.3"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c15078"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2014.20.1.6"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.02.009"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjco.2020.04.011"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.110200"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201085170\u20104"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.09.22"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl\u20102015\u2010307467"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep08840"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.07.009"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.21.2035"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/mi16010014"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00348\u2010019\u20102678\u20105"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00348-007-0276-4"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202400643"},{"issue":"3","key":"e_1_2_9_59_1","article-title":"Validation of Ultrasound Velocimetry and Computational Fluid Dynamics for Flow Assessment in Femoral Artery Stenotic Disease","volume":"11","author":"Velde L.","year":"2024","journal-title":"Journal of Medical Imaging"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2021.09.020"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.70128"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2023.100869"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201003651\u20108"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2006.08.009"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27376"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109440(10)63487\u20106"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i34.5429"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001852\u2010x"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569\u2010021\u201000517\u20104"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3522"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000106321.63667.24"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.176347"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.5114\/wo.2012.27340"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02\u20100634rev"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028181"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5673"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i20.2482"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24282"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1098129"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43152\u2010021\u201000030\u20103"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9040929"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000207"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1177\/019262339602400114"},{"issue":"9","key":"e_1_2_9_84_1","first-page":"2072","article-title":"Role of Liver Sinusoidal Endothelial Cells in Liver Regeneration and the Development of Liver Fibrosis","volume":"35","author":"ZiYue Y.","year":"2019","journal-title":"Journal of Clinical Hepatology"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1126\/stke.3062005re12"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.01.021"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.46.27865"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25497"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.14839.1"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11626\u2010021\u201000625\u2010y"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24086875"},{"issue":"6","key":"e_1_2_9_92_1","first-page":"1083","article-title":"Hypoxia Increases the Abundance but Not the Assembly of Extracellular Fibronectin during Epithelial Cell Transdifferentiation","volume":"128","author":"Rana M. K.","year":"2015","journal-title":"Journal of Cell Science"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.01.012"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.06.010"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478\u20103231.2006.01365.x"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2023.100722"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph18060893"},{"issue":"4","key":"e_1_2_9_98_1","first-page":"G624","article-title":"Endothelin\u20101 Induces Direct Constriction of Hepatic Sinusoids","volume":"266","author":"Zhang J. X.","year":"1994","journal-title":"American Journal of Physiology"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478\u20103231.2011.02579.x"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2011.03.005"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252312859"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.05.004"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2016.08.001"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040\u20104603.2013.tb00517.x"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2016.49.3.188"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb44070218"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2023.06.002"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2022.100754"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2019.02.016"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/cld.681"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441\u2010011\u20101246\u2010y"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13665"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1369\/0022155415627681"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010018\u20100020\u2010y"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2016.5"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201045114\u20101"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202400476"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.110770"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202302271"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014490"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0sm00691b"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.33008"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100968"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202001169"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13071099"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1557\/JMR.1992.1564"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.3390\/mi11040366"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00348\u2010005\u20100016\u20106"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202524337","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202524337","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202524337","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202524337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T14:23:17Z","timestamp":1781533397000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202524337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,8]]},"references-count":127,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/advs.202524337"],"URL":"https:\/\/doi.org\/10.1002\/advs.202524337","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,8]]},"assertion":[{"value":"2025-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e24337"}}