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However, their efficacy has been limited. Deep brain stimulation (DBS) via implanted electrodes has been shown to promote neurogenesis in vitro and in vivo. Still, its invasiveness precludes deployment in research and widespread clinical use. Temporal interference (TI) has emerged as a strategy for non\u2010invasive, high\u2010precision DBS using multiple kHz\u2010range electric fields to target the deep brain. Here, we validate the potential of TI stimulation for neural regeneration augmentation in the central nervous system (CNS). First, we showed that TI stimulation modulated at the theta\u2010band frequency enhances the maturation of embryonic neural progenitor cells in vitro. We then demonstrate that theta\u2010band TI stimulation targeting the hippocampus enhances endogenous hippocampal neurogenesis in an in vivo mouse model of Alzheimer's disease\u2010like amyloidosis. By uncovering frequency\u2010specific control of stem cell fate, we propose a clinically relevant regeneration strategy that avoids pharmacological or genetic manipulation. Our results enable focal, non\u2010invasive augmentation of deep\u2010brain neural regeneration via electrical stimulation.<\/jats:p>","DOI":"10.1002\/advs.202524341","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:48:26Z","timestamp":1777369706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Temporal Interference Stimulation Enhances Neural Regeneration"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3474-6807","authenticated-orcid":false,"given":"Sofia","family":"Peressotti","sequence":"first","affiliation":[{"name":"Bioengineering Department Imperial College London South Kensington  London UK"},{"name":"Department of Brain Sciences Imperial College London Hammersmith Hospital  London UK"},{"name":"UK Dementia Research Institute  London UK"},{"name":"Psychiatry and Fundamental Neuroscience Department University of Geneva  Geneva 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