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Achieving sustained inhibition of chondrocyte senescence while mitigating multifactorial cellular stressors remains challenging in aged OA treatment. In this study, an injectable bioadhesive and lubricating hydrogel, encapsulating miR\u2010140\u20105p (miR\u2010140)\u2010loaded and polyphenol\u2010armored nanoparticles, was developed for rejuvenating senescent chondrocytes in aged OA. Originating from catechol groups, the hydrogel anchors firmly to cartilage tissues, facilitating a sustained reduction in joint friction. It also acts as a local depot for nanoparticles, prolonging their retention within the harsh joint cavity. The polyphenol armor on the nanoparticles preserves miR\u2010140 activity in the RNase\u2010 and ROS\u2010rich senescence microenvironment, prevents premature leakage, and enhances transfection efficiency by overcoming extracellular matrix, cell membrane, and lysosomal barriers. This contributes to the downregulation of senescence\u2010associated signaling pathways in chondrocytes. Furthermore, the polyphenol armor exhibits catalase\u2010 and superoxide\u2010dismutase\u2010like activity, mitigating mitochondrial dysfunction through targeted ROS scavenging. By integrating these advanced attributes, the hydrogel attenuated chondrocyte senescence and OA progression in an aged rat model, showing great prospects in clinical application.<\/jats:p>","DOI":"10.1002\/advs.202600014","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T15:15:48Z","timestamp":1779290148000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bioadhesive Hydrogel With Polyphenol\u2010Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy"],"prefix":"10.1002","volume":"13","author":[{"given":"Liwei","family":"Yan","sequence":"first","affiliation":[{"name":"Sports Medicine Center Department of Orthopedic Surgery\/Orthopedic Research Institute West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Institute of Biomedical Engineering College of Medicine Southwest Jiaotong University Chengdu 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