{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:55:11Z","timestamp":1790603711412,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"54","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Thrombotic vascular diseases contribute to significant global mortality, yet current therapeutic strategies face persistent challenges, including bleeding risks, suboptimal efficiency, and procedural complexity. Here, we report a micro\u2010explosive thermochemical thrombolysis (METCT) therapy via proximal injection of liquid alkali metal (LAM) encapsulated in dimethyl silicone (LAM@oil), which enables prompt, efficient, and safe vascular recanalization within an ultrafast timeframe (&lt; 90 s). This LAM@oil system effectively disrupts thrombus tissue through a synergistic triple\u2010action mechanism: mechanical micro\u2010explosions forces, alkaline ablation due to highly localized exothermic chemical reactions, and thermal thrombolysis mediated by elevated temperature. Upon thrombolysis completion, the non\u2010toxic reaction byproducts (sodium and potassium ions) exhibit physiologically biocompatible and metabolizable effects. Critically, the LAM@oil demonstrates significantly higher thrombolytic efficacy compared to clinically available thrombolytic drugs (residual thrombus area percent 10.87%\u00a0\u00b1\u00a07.16% for LAM@oil vs. 80.86%\u00a0\u00b1\u00a013.32% for urokinase), with no associated bleeding risks. This strategy opens a byproduct\u2010green, cost\u2010effective, and high\u2010efficiency alternative to conventional thrombolytics, holding big potential for clinical translation in acute thrombosis management.<\/jats:p>","DOI":"10.1002\/advs.202600039","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:15:45Z","timestamp":1783080945000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thermochemical Micro\u2010Explosion for Prompt Thrombolysis via Proximal Injection of Liquid Alkali Metal"],"prefix":"10.1002","volume":"13","author":[{"given":"Xin","family":"Liao","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Hou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cryogenic Science and Technology and Beijing Key Laboratory of CryoBiomedicine Technical Institute of Physics and Chemistry Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cryogenic Science and Technology and Beijing Key Laboratory of CryoBiomedicine Technical Institute of Physics and Chemistry Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Materials Research &amp; Center of Double Helix Shenzhen International Graduate School Tsinghua University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cryogenic Science and Technology and Beijing Key Laboratory of CryoBiomedicine Technical Institute of Physics and Chemistry Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Qu","sequence":"additional","affiliation":[{"name":"Xiyuan Hospital of China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4168-0298","authenticated-orcid":false,"given":"Wei","family":"Rao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cryogenic Science and Technology and Beijing Key Laboratory of CryoBiomedicine Technical Institute of Physics and Chemistry Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0844-5296","authenticated-orcid":false,"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Tsinghua University  Beijing China"},{"name":"State Key Laboratory of Cryogenic Science and Technology and Beijing Key Laboratory of CryoBiomedicine Technical Institute of Physics and Chemistry Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06797"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.83"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/6117810"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.0835"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00270\u2010005\u20100341\u20104"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000820"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21079"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002\u20109343(98)00355\u20106"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042098615572333"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.11.047"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.7193"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2019.122109"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.121.035457"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/17474930211021353"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2017.08.010"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2017.12.025"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319712470966"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20210003"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201050557\u2010w"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13204\u2010018\u20100856\u2010z"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2018.01.006"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2017.12.008"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010019\u20100567\u2010y"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00258"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201011193\u2010x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.6b01632"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.16.7"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100520"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201035895\u20105"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adk7251"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201009049\u20100"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551\u2010025\u201001382\u2010z"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz9014"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c09986"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202304441"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201042691\u20108"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aed9464"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2ta06882f"},{"key":"e_1_2_10_40_1","volume-title":"Sodium\u2014NaK Engineering Handbook","author":"Foust O. J.","year":"1972"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.13182\/nse160\u201075"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anucene.2020.107576"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202201956"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656730802228465"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/13645700701803826"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/13645700802384023"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/13645706.2017.1330758"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.111.244608"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202301039"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.8b00979"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201404354"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202600039","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202600039","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202600039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T12:58:02Z","timestamp":1790600282000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202600039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,3]]},"references-count":50,"journal-issue":{"issue":"54","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/advs.202600039"],"URL":"https:\/\/doi.org\/10.1002\/advs.202600039","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,3]]},"assertion":[{"value":"2026-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00039"}}