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Inspired by the natural cartilage lubrication mechanism, we propose a two\u2010step injection strategy to construct a biomimetic synergistic lubrication coating in situ on cartilage surfaces. The administration of developed cationic biomimetic lubricant (CS\u2010g\u2010PM) as the first injection to capture the subsequently administered HA via in situ self\u2010assembly on the cartilage surface, forming a natural cartilage\u2010like lubrication layer. In vitro, this strategy reduced friction coefficients to normal cartilage levels in OA human cartilage. Moreover, sequential CS\u2010g\u2010PM and HA articular\u2010injection in OA rats extended HA retention 5\u2010fold versus HA alone; meanwhile, regeneration of cartilage was synergistically promoted. Importantly, a first\u2010in\u2010human pretrial demonstrated rapid MRI\u2010evident cartilage repair at 1 month. At 6 months of follow\u2010up, patients showed sustained functional improvement and halted structural degeneration. This strategy offers a transformative solution for OA treatment.<\/jats:p>","DOI":"10.1002\/advs.202600049","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T15:19:51Z","timestamp":1775834391000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Biomimetic Lubricant Captures Hyaluronic Acid In Situ to Regenerate Cartilage: From Bench to Bedside"],"prefix":"10.1002","volume":"13","author":[{"given":"Yongan","family":"Lin","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering South China University of Technology  Guangzhou China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction  Guangzhou China"},{"name":"Guangzhou National Laboratory Guangzhou International BioIsland  Guangzhou China"},{"name":"Guangzhou Proud Seeing Biotechnology Co., Ltd.  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