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Here, we engineered a stage\u2010adaptive Janus microneedle patch (MN\u2010FeSAC\u2010PPE) to enable a staged therapeutic process from early antibacterial intervention to subsequent redox\u2013immune microenvironment remodeling and regenerative tissue repair. This stage\u2010adaptive design integrates Fe single\u2010atom nanozymes (Fe\u2010SACs) into the microneedle base to rapidly kill bacteria using near\u2010infrared light, which activates reactive oxygen species (ROS) production, enabling rapid antibacterial activity against wound pathogens. Meanwhile, propolis extract\u2010loaded (PPE) tips deliver antioxidant bioactive compounds into the wound bed to mitigate oxidative stress, modulate the redox\u2010immune microenvironment, and support the inflammatory\u2010to\u2010regenerative transition. In vitro, MN\u2010FeSAC\u2010PPE enhanced antioxidant defense, suppressed pro\u2010inflammatory factors, and protected fibroblasts from oxidative stress\u2010induced mitochondrial dysfunction. Transcriptomic analysis further supported reduced inflammatory signaling and enhanced metabolism\u2010related programs. In\n                    <jats:italic>S. aureus<\/jats:italic>\n                    \u2010infected diabetic wounds, NIR\u2010activated MN\u2010FeSAC\u2010PPE accelerated wound closure, promoted angiogenesis and collagen remodeling, and alleviated inflammation. These findings establish a stageadaptive redox\u2010immune and bioenergetic regulatory microneedle platform for infected diabetic wound repair.\n                  <\/jats:p>","DOI":"10.1002\/advs.202600076","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:57:10Z","timestamp":1785333430000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Stage\u2010Adaptive Janus Microneedle System for Redox\u2010Immune Regulation and Mitochondrial Protection in Infected Diabetic Wound Healing"],"prefix":"10.1002","volume":"13","author":[{"given":"Mengting","family":"Yin","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases Shanghai Stomatological Hospital &amp; School of Stomatology Fudan University  Shanghai People's Republic of China"},{"name":"Center for Orthopaedic Science and Translational Medicine Department of Orthopaedics 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