{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T03:21:12Z","timestamp":1785813672678,"version":"3.56.0"},"reference-count":46,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Efficient lithium extraction from brines remains challenging due to the comparable hydrated radii of Li\n                    <jats:sup>+<\/jats:sup>\n                    and Mg\n                    <jats:sup>2+<\/jats:sup>\n                    and the extreme ionic strength of the feed solutions. In this work, a reconstructed polyamide (PA) nanofiltration membrane was developed via a two\u2010stage interfacial polymerization strategy, achieving simultaneous structural and electrostatic engineering of the PA selective layer. In the first stage, the relationship between substrate physicochemical properties and the resulting density and stability of the nascent polyamide layer was established through regulation of piperazine (PIP) adsorption\u2010diffusion behavior. In the second stage, careful selection of a non\u2010aqueous solvent effectively suppressed acyl chloride hydrolysis and preserved abundant active sites, allowing the successful incorporation of a bidentate quaternary ammonium monomer into the newly formed PA network. This reconstruction generated a confined sub\u2010nanometer selective layer with a tunable mild positive charge, enabling synergistic steric and electrostatic discrimination between Li\n                    <jats:sup>+<\/jats:sup>\n                    and Mg\n                    <jats:sup>2+<\/jats:sup>\n                    . The optimized membrane exhibited excellent Li\n                    <jats:sup>+<\/jats:sup>\n                    \/Mg\n                    <jats:sup>2+<\/jats:sup>\n                    separation factors that exceeded 60 under diverse operating conditions, while the integrated nanofiltration process achieved nearly 60\u2010fold lithium enrichment, demonstrating a practical applicability in complex brine matrices. This study establishes a generalizable molecular\u2010level design reference for co\u2010ion selective membranes capable of lithium extraction under chemically demanding, high\u2010ionic\u2010strength conditions.\n                  <\/jats:p>","DOI":"10.1002\/advs.74368","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T06:46:32Z","timestamp":1771397192000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Reconstructed Polyamide Nanolayers via Two\u2010Stage Interfacial Polymerization Engineering for Precise Ion Sieving"],"prefix":"10.1002","volume":"13","author":[{"given":"Shuzhen","family":"Zhao","sequence":"first","affiliation":[{"name":"Research Center for Membrane and Film Technology Kobe University  Kobe Japan"},{"name":"Department of Chemical Science and Engineering Kobe University  Kobe 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