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To overcome this, we developed an enzyme\u2010activated magnetic resonance imaging strategy (eaMRI) using a biodegradable nanoprobe, CrGOx@Lip, that integrates endogenous Cr\n                    <jats:sup>3+<\/jats:sup>\n                    ions with glucose oxidase for glucose\u2010responsive imaging. Our approach leverages GOx not only as a catalytic engine to specifically oxidize glucose but also as a structural template to guide the in\u2010situ synthesis of a potent MRI reporter (paramagnetic chromium gluconate). This design enables direct, specific amplification of MRI signals in proportion to local glucose concentration, achieving an 8.28\u2010fold relaxivity increase. We validated this method for sensitive glucose mapping in vivo, including delineating Warburg\u2010effect\u2010driven tumors and quantifying pathological glucose accumulation in metabolic dysfunction\u2010associated fatty liver disease (\u0394SNR% = 18.51 \u00b1 3.72\u00a0vs. 1.14 \u00b1 1.39 in controls;\n                    <jats:italic>p<\/jats:italic>\n                    &lt;0.001), and further demonstrated its utility in monitoring therapeutic efficacy via glucose\u2010responsive signal changes. By synergizing enzymatic precision with nanomaterial engineering, our CrGOx@Lip\u2010mediated eaMRI platform provides a glucose\u2010specific, radiation\u2010free, and non\u2010invasive strategy for sensitive metabolic diagnostics in precision medicine.\n                  <\/jats:p>","DOI":"10.1002\/advs.74861","type":"journal-article","created":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T18:38:10Z","timestamp":1773599890000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enzyme\u2010Activated MRI for In Vivo Glucose Imaging via a Biodegradable Chromium Nanoprobe"],"prefix":"10.1002","volume":"13","author":[{"given":"Yan","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Radiology Tongji Hospital Shanghai Frontiers Science Center of Nanocatalytic Medicine the Institute for Biomedical Engineering &amp; Nano Science School of Medicine Tongji University Shanghai China"},{"name":"Shanghai Key Laboratory of Molecular Imaging Shanghai Pudong New Area Gongli Hospital Affiliated Shanghai University of Medicine and Health Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1657-292X","authenticated-orcid":false,"given":"Weitao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology Tongji Hospital Shanghai Frontiers Science Center of Nanocatalytic Medicine the Institute for Biomedical Engineering &amp; Nano Science School of Medicine Tongji University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjing","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Radiology Tongji Hospital Shanghai Frontiers Science Center of Nanocatalytic Medicine the Institute for Biomedical Engineering &amp; Nano Science School of Medicine Tongji University Shanghai 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