{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:12:04Z","timestamp":1792638724974,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"31","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572292"],"award-info":[{"award-number":["82572292"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Ferroptosis, a newly recognized form of regulated cell death, has emerged as a promising strategy in cancer therapy. Given the high incidence and recurrence rates of bladder cancer, exploring novel therapeutic approaches is critically important. In this study, we developed a novel intravesical nanoplatform, FBZ@BSA@PDA, that integrates ferroptosis\u2010related oxidative injury immunogenic cell death (ICD) activation, and photothermal therapy (PTT) to achieve synergistic treatment of bladder cancer. The hydrophobic drug fenbendazole (FBZ) was efficiently encapsulated via thermally induced unfolding of bovine serum albumin (BSA), and polydopamine (PDA) was formed by in situ polymerization of dopamine to enhance tissue adhesion and photothermal responsiveness. Following transurethral intravesical administration, the platform enabled sustained drug release and localized PTT. Mechanistically, it induced lipid peroxidation (LPO), GSH depletion, and mitochondrial dysfunction, which suggest that ferroptosis may contribute to tumor cell death. This was accompanied by key ICD markers, including calreticulin (CRT) exposure, high mobility group box 1 (HMGB1) release, and adenosine triphosphate (ATP) secretion, which effectively promoted dendritic cell (DC) maturation and T\u2010cell activation. FBZ@BSA@PDA demonstrated strong anti\u2010tumor efficacy and favorable biosafety in an orthotopic mouse model of bladder cancer. This strategy offers a promising localized immune\u2010potentiated therapeutic approach for clinical bladder cancer treatment.<\/jats:p>","DOI":"10.1002\/advs.74876","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T18:46:08Z","timestamp":1774032368000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ferroptosis Induction by Fenbendazole Combined With Photothermal Therapy Triggers Dual\u2010Immunotherapy Against Bladder Cancer"],"prefix":"10.1002","volume":"13","author":[{"given":"Xiaojian","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Urology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Urology South China Hospital Medical School Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anguo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Urology The Fourth Affiliated Hospital of Soochow University Medical Center of Soochow University Suzhou Dushu Lake Hospital  Suzhou China"},{"name":"Department of Urology South China Hospital Medical School Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9416-3713","authenticated-orcid":false,"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongkang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology South China Hospital Medical School Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology South China Hospital Medical School Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dashi","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Urology The Affiliated Luohu Hospital of Shenzhen University Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Urology South China Hospital Medical School Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology The Affiliated Luohu Hospital of Shenzhen University Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Urology South China Hospital Medical School Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4295-370X","authenticated-orcid":false,"given":"Miao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuedong","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Urology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology South China Hospital Medical School Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5324-9094","authenticated-orcid":false,"given":"Liang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute of Functional Nano &amp; Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon Based Functional Materials &amp; Devices Soochow University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianquan","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Urology The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Department of Urology The Fourth Affiliated Hospital of Soochow University Medical Center of Soochow University Suzhou Dushu Lake Hospital  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0000000000000594"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57080749"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010023\u201000468\u20109"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2022.10.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.17598"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21631"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175024"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol31020079"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110393"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2020.1810016"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1170124"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202505669"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010020\u201000324\u20108"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422\u2010020\u201000441\u20101"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2022.03.022"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010020\u201000462\u20100"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S269321"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2025.113015"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2021.100197"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202209748"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adq3870"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122570"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010024\u201000920\u20109"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpx.2025.100400"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2024.14691"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.202400084"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010024\u201003146\u20100"},{"key":"e_1_2_9_29_1","first-page":"842","article-title":"Effects of Dietary Bacillus Velezensis on Growth Performence, Immunity, Intestinal Microbiota and Resistance Against Aeromonas Hydrophila in Juvenile Largemouth Bass","volume":"18","author":"Zhao A.","year":"2023","journal-title":"(Micropterus Salmoides)"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010020\u20102298\u20102"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018\u2010025\u201001037\u20107"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010022\u201001132\u20102"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.114203"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1581951"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113085"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202500337"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.74876","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.74876","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.74876","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T12:03:24Z","timestamp":1782993804000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.74876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,20]]},"references-count":35,"journal-issue":{"issue":"31","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/advs.74876"],"URL":"https:\/\/doi.org\/10.1002\/advs.74876","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,20]]},"assertion":[{"value":"2025-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e74876"}}