{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T12:45:48Z","timestamp":1782996348328,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","issue":"31","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874118"],"award-info":[{"award-number":["81874118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82573140"],"award-info":[{"award-number":["82573140"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023QH456"],"award-info":[{"award-number":["ZR2023QH456"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Lung metastasis accounts for the majority of deaths in patients with triple\u2010negative breast cancer (TNBC). The interaction between tumor cells and vascular endothelial cells (VECs) plays a crucial role during cancer metastasis. Sohlh2 is known as a tumor suppressor gene in the breast cancer progression. However, the role of Sohlh2 in the crosstalk of VECs and tumor cells remain unclear. The results of tissue microarray show that low Sohlh2 expression in VECs is associated with poor prognosis, and metastasis in clinical TNBC patients. Functional studies reveal that overexpression Sohlh2 in VECs could repress the adhesion and trans\u2010endothelial migration of TNBC cells, attenuate EC senescence, increased permeability, and inflammation induced by TNBC cells. Endothelial cell\u2010specific knock in Sohlh2 suppresses TNBC lung metastasis. Moreover, mechanism studies show that Sohlh2 represses NF\u2010\u03baB signaling pathway activation by promoting Sirt1 transcription in VECs. PRMT5\u2010mediated Sohlh2 arginine methylation promotes the CUL4B\u2010mediated ubiquitylation and degradation of Sohlh2, leading to the inhibition of Sohlh2 effects in VECs. Taken together, these findings demonstrate that PRMT5\/Sohlh2\/Sirt1 signaling pathway in VECs plays a critical role in regulating the lung metastasis in TNBC, indicating PRMT5\/Sohlh2\/Sirt1 signaling as potential targets in the treatment of TNBC metastasis.<\/jats:p>","DOI":"10.1002\/advs.74884","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T08:36:19Z","timestamp":1774254979000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["PRMT5\/Sohlh2\/Sirt1 Signaling Pathway in Vascular Endothelial Cells Modulates Lung Metastasis of Triple\u2010Negative Breast Cancer"],"prefix":"10.1002","volume":"13","author":[{"given":"Ruihong","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of The Ministry of Education for Experimental Teratology, Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengqin","family":"Wang","sequence":"additional","affiliation":[{"name":"Advanced Medical Research Institute Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanlan","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of The Ministry of Education for Experimental Teratology, Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of The Ministry of Education for Experimental Teratology, Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoning","family":"Huo","sequence":"additional","affiliation":[{"name":"Key Laboratory of The Ministry of Education for Experimental Teratology, Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Nan","sequence":"additional","affiliation":[{"name":"Key Laboratory of The Ministry of Education for Experimental Teratology, Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Dong","sequence":"additional","affiliation":[{"name":"Key Laboratory of The Ministry of Education for Experimental Teratology, Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunling","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Hao","sequence":"additional","affiliation":[{"name":"Key Laboratory of The Ministry of Education for Experimental Teratology, Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2020.06.005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33629"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010021\u201000565\u20102"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201006\u20103045"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(16)31891\u20108"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.4147"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abn7571"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3628"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvw166"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.12.012"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2022.04.001"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11091502"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201015\u20102302"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32209"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07813"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12690"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15346"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222011097"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600244"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40659\u2010023\u201000461\u20102"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313143"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.01.001"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541\u20107786.MCR\u201020\u20100771"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22989"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010023\u201006383\u2010x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.4A6514.2005"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.323299"},{"key":"e_1_2_9_29_1","first-page":"2267","article-title":"Asparaginyl Endopeptidase Induces Endothelial Permeability and Tumor Metastasis via Downregulating Zonula Occludens Protein ZO\u20101","volume":"2019","author":"Kang L.","year":"1865","journal-title":"Biochimica et Biophysica Acta (BBA)\u2010Molecular Basis of Disease"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.07.020"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010019\u20100836\u20100"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abm8965"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI124884"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010022\u201002927\u20108"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00377-2021"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753\u2010023\u201001848\u20109"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201035795\u20108"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2022.101097"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.42047"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa065"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2011.09.001"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad5214"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae387"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc1834"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2004.08.011"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2008.01.044"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20040373"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2023.05.006"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.74884","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.74884","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.74884","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T12:01:38Z","timestamp":1782993698000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.74884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,23]]},"references-count":47,"journal-issue":{"issue":"31","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/advs.74884"],"URL":"https:\/\/doi.org\/10.1002\/advs.74884","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,23]]},"assertion":[{"value":"2025-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e74884"}}