{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T12:46:09Z","timestamp":1782996369831,"version":"3.54.5"},"reference-count":48,"publisher":"Wiley","issue":"31","license":[{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82220108008"],"award-info":[{"award-number":["82220108008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A previously successful pregnancy promotes the fitness of subsequent pregnancies, of which the pregnancy\u2010induced memory is ascribed exclusively to adaptive lymphocytes. However, whether macrophages at maternal\u2010fetal interface acquire pregnancy\u2010specific immune memory remains unclear. Using human decidual samples and complementary mouse models, we identify human leukocyte immunoglobulin\u2010like receptor subfamily B3\n                    <jats:sup>+<\/jats:sup>\n                    (LILRB3\n                    <jats:sup>+<\/jats:sup>\n                    ) and murine paired immunoglobulin\u2010like receptor B\n                    <jats:sup>+<\/jats:sup>\n                    (PIR\u2010B\n                    <jats:sup>+<\/jats:sup>\n                    ) macrophages as a uterine memory subset, which expands progressively with gravidity and gestational age, and exhibits paternal specific immune memory. In both species, these cells exhibited hallmarks of pregnancy\u2010induced trained tolerance, including elevated IL\u201010, TGF\u2010\u03b2, and CD206, together with reduced CD80\/CD86 expression and suppression of pro\u2010inflammatory cytokines. Mechanistically, PIR\u2010B\u2010SHP signaling drives macrophage metabolic reprogramming to oxidative phosphorylation\/fatty acid oxidation for the formation of memory. Moreover, adoptive transfer of PIR\u2010B\n                    <jats:sup>+<\/jats:sup>\n                    uterine macrophages into abortion\u2010prone mouse models significantly improves pregnancy outcomes, highlighting their therapeutic potential. Together, our findings uncover a previously unrecognized form of decidual macrophage trained memory in an antigen\u2010specific manner, which opens avenues for therapeutic strategies aimed at preventing or reducing recurrent pregnancy loss.\n                  <\/jats:p>","DOI":"10.1002\/advs.74889","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:27:48Z","timestamp":1774686468000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Trained Memory of Uterine Macrophages Improves Subsequent Pregnancy Outcomes"],"prefix":"10.1002","volume":"13","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Reproductive Health Center for Reproductive Medicine Tongji Medical College Huazhong University of Science and Technology  Wuhan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Health Center for Reproductive Medicine Tongji Medical College Huazhong University of Science and Technology  Wuhan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010Xiu","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Health Center for Reproductive Medicine Tongji Medical College Huazhong University of Science and Technology  Wuhan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu\u2010Hui","family":"Fang","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Health Center for Reproductive Medicine Tongji Medical College Huazhong University of Science and Technology  Wuhan P.R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Mor","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Health Center for Reproductive Medicine Tongji Medical College Huazhong University of Science and Technology  Wuhan P.R. China"},{"name":"C.S. Mott Center for Human Growth and Development Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8533-8315","authenticated-orcid":false,"given":"Ai\u2010Hua","family":"Liao","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Health Center for Reproductive Medicine Tongji Medical College Huazhong University of Science and Technology  Wuhan P.R. 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