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We uncover a trichome\u2010enriched CsYABBY3\u2010CsAS1 transcriptional module that links glandular trichome differentiation with cannabinoid biosynthesis in cannabis. CsYABBY3, a FILAMENTOUS FLOWER (FIL)\/YAB3\u2010family transcription factor, promotes glandular trichome formation and elevates total cannabinoid levels. It directly binds a conserved TAATTAA motif in the promoters of\n                    <jats:italic>CsPT4<\/jats:italic>\n                    and\n                    <jats:italic>CsCBDAS<\/jats:italic>\n                    , activating their transcription. The R2R3\u2010MYB CsAS1 can also stimulate cannabinoid pathway gene expression independently, but its activity is enhanced in partnership with CsYABBY3. The two factors physically associate and reciprocally upregulate each other, forming a positive feedback loop that amplifies target\u2010gene output. A single residue (M199) in CsYABBY3 is required for CsAS1 interaction and cooperative promoter activation. Comparative evidence suggests broadly conserved FIL\/YAB3\u2010AS1 coupling across species, alongside lineage\u2010specific differences in the molecular basis of complex formation. These findings define an engineerable regulatory circuit that connects trichome fate with specialized metabolism and provide a practical route to improve cannabinoid yield.\n                  <\/jats:p>","DOI":"10.1002\/advs.75055","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T18:26:12Z","timestamp":1775154372000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Novel CsYABBY3\u2010CsAS1 Feedback Loop Coordinates Trichome Differentiation and Cannabinoid Biosynthesis in\n                    <i>Cannabis sativa<\/i>\n                    L."],"prefix":"10.1002","volume":"13","author":[{"given":"Xuewen","family":"Zhu","sequence":"first","affiliation":[{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao\u2010di Herbs Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences  Beijing 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