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However, their effectiveness is constrained by insufficient intracellular iron\/copper levels, unintended toxicity to healthy cells. Here, we developed a self\u2010amplifying, targeted nanocomposite (ct@HMCF\u2010Dex) based on hollow mesoporous copper\u2010iron sulfide (HMCF), citric acid (ct), and dextran (Dex), which specifically triggers extracellular bacterial cuproptosis\/ferroptosis, effectively treating MRSA lung infections and wound infections. Under the bacterial\u2010infected microenvironment, ct@HMCF\u2010Dex can release Cu\n                    <jats:sup>2+<\/jats:sup>\n                    , Fe\n                    <jats:sup>3+<\/jats:sup>\n                    , S\n                    <jats:sup>2\u2212<\/jats:sup>\n                    and citric acid in response to the acidic environment, thereby triggering a series of amplified oxidative stress reactions. During this process, S\n                    <jats:sup>2\u2212<\/jats:sup>\n                    generates H\n                    <jats:sub>2<\/jats:sub>\n                    S under acidic conditions, inhibiting the activity of catalase and causing a synergistic effect of local acidification and accumulation of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    . Cu\n                    <jats:sup>2+<\/jats:sup>\n                    \/Fe\n                    <jats:sup>3+<\/jats:sup>\n                    disrupts redox balance by depleting glutathione while sustaining Cu\n                    <jats:sup>+<\/jats:sup>\n                    \/Fe\n                    <jats:sup>2+<\/jats:sup>\n                    release via redox cycling. Citric acid chelates Cu\n                    <jats:sup>+<\/jats:sup>\n                    \/Fe\n                    <jats:sup>2+<\/jats:sup>\n                    , prolonging their activity for lipid peroxidation, and activates the tricarboxylic acid (TCA) cycle, synergizing with cysteine depletion to induce cuproptosis\/ferroptosis\u2010like death. This process generates stable hydroxyl radicals (\u2022OH) and effectively clearing free bacteria and disrupting biofilms through a synergistic mechanism. This study presents a precise strategy to combat stubborn infections by triggering targeted bacterial cuproptosis\/ferroptosis\u2010like death.\n                  <\/jats:p>","DOI":"10.1002\/advs.75101","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T18:17:18Z","timestamp":1775153838000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Self\u2010Amplifying Redox Cycle Triggers Ferroptosis\/Cuproptosis Synergy for Enhanced Bacterial Eradication"],"prefix":"10.1002","volume":"13","author":[{"given":"Zehui","family":"Xiao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Nutrition and Safety College of Food Science and Engineering Tianjin University of Science and Technology  Tianjin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaolong","family":"Qiu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Nutrition and Safety College of Food Science and Engineering Tianjin University of Science and Technology  Tianjin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangli","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Nutrition and Safety College of Food Science and Engineering Tianjin University of Science and Technology  Tianjin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jifeng","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Nutrition and Safety College of Food Science and Engineering Tianjin University of Science and Technology  Tianjin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Song","sequence":"additional","affiliation":[{"name":"College of Chemistry Huazhong Agricultural University  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Du","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Nutrition and Safety College of Food Science and Engineering Tianjin University of Science and Technology  Tianjin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjun","family":"Du","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Nutrition and Safety College of Food Science and Engineering Tianjin University of Science and Technology  Tianjin P. R. 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